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A 15-Year Study of Osseointegrated Implants in the Treatment of the Edentulous Jaw
Published in Niall MH McLeod, Peter A Brennan, 50 Landmark Papers every Oral & Maxillofacial Surgeon Should Know, 2020
If osseointegration was not achieved, supplementary implants were placed after removal and healing of the bone. The percentage of supplementary implants and the distribution among groups II and III were calculated.
Animal Models for Investigations of Biomaterial Debris
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Martin Lind, Yong Song, Stuart B. Goodman
The bone harvest chamber (Figure (1) is a Ti device that is implanted in the proximal tibial metaphyses of mature male NZW rabbits. The chamber has a 1 × 1 × 10 mm pore for tissue ingrowth at the cortical bone level. The top of the chamber can be accessed through a small skin incision and be disassembled for tissue harvest or particle application. In these studies chambers were inserted bilaterally. After osseointegration, repeated harvests of tissue growing into the chamber are possible. The particles investigated were machined high density polyethylene (HDPE), hydroxyapatite (HA), Ti6A14V alloy and CoCr alloy particles with 4.7, 5.0, 3.0 and 2.7 pm mean diameter respectively. Also diamond and SiC particles with a <20 μm size were investigated. Particles were dissolved in sodium hyaluronate at a concentration of 1 × 108 particles/ml. Initially a six week osseointegration period was applied. Then the carrier material (Healon) was placed bilaterally for three weeks. Tissues were harvested and HDPE particles were placed in the chambers on one side and the contralateral side was left empty as control. After another three weeks tissues were harvested. The previous control side now received titanium alloy (Ti alloy) particles and the contralateral side served as control for a final three weeks.
Studying the mandible bone tissue remodelling in the vicinity of implants using a meshless method computational framework
Published in J. Belinha, R.M. Natal Jorge, J.C. Reis Campos, Mário A.P. Vaz, João Manuel, R.S. Tavares, Biodental Engineering V, 2019
H.I.G. Gomes, J. Belinha, R.M. Natal Jorge
The placement of dental implants is currently a valid treatment and with a high success rate (Zupnik, Kim, Ravens, Karimbux, & Guze, 2011). Nowadays, there are several types of implants, which can be classified according to their macro and microstructure. The characteristics of the implant aim to increase primary stability, a factor that is essential for osseointegration. Although there is no concrete definition for “primary stability”, this is usually understood as the lack of mobility of the implant immediately after its placement (Neukam & Flemmig, 2006). Thus, for implant success to occur, bone tissue development must occur during osseointegration and bone remodelling. Osseointegration usually occurs in the peri-implant region within the first three to six months after surgery. Subsequently, the implant increases the stability through the deeper bone remodelling, that is, in the deeper cortical and trabecular bone. After a certain healing period, a state of equilibrium remodelling is achieved, where bone loss is minimal, and the implant failure rate is low.
TiO2 nanotubes regulate histone acetylation through F-actin to induce the osteogenic differentiation of BMSCs
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Yanchang Liu, Zhicheng Tong, Chen Wang, Runzhi Xia, Huiwu Li, Haoran Yu, Juehua Jing, Wendan Cheng
Osseointegration refers to the orderly structure and functional connection between the surface of the implant and the host bone [1]. After implantation, good osseointegration at the interface is the basis of long-term stability of the prosthesis and the key to the success of the implantation [2]. At present, TiO2 nanotubes have become one of the most commonly used modification techniques for prosthesis and bone defect implants due to their good biocompatibility, mechanical properties and chemical stability [3]. On the one hand, titanium is used as a metal material to maintain a good balance between mechanical properties and corrosion resistance [4]. On the other hand, the unique surface porosity and substrate stiffness of TiO2 nanotubes have significant effects on cell adhesion, survival, differentiation and growth [5]. For example, the new studies shows that as the diameter of the TiO2 nanotube increases, the integration effect of the prosthesis and the host bone will be better. However, a excessive diameter will reduce the adhesion ability of cells [6,7]. The dense arrangement of nanotubes promotes the spreading and mineralization of osteoblasts on the surface, resulting in producing new bone faster [8]. The microstructure of TiO2 nanotubes can be accurately controlled by adjusting the parameters of electrolyte composition, voltage and oxidation time in electrochemical anodic oxidation [9]. Such TiO2 nanotubes morphology can induce bone marrow mesenchymal stem cells (BMSCs) to differentiate into osteoblasts and promote bone tissue formation, but the specific regulatory mechanisms have not been fully elucidated.
Modified Disk-Up Sinus Reamer for Sinus Floor Elevation and Simultaneous Implant Placement: An Animal Study with Miniature Pigs
Published in Journal of Investigative Surgery, 2020
Hang-Ying Jin, Min-Hua Teng, Duode Wang, Xin Li, Jia-Yue Liang, Wen-Xue Wang, Shuai Jiang, Bao-Dong Zhao
Grafting group: only one implant appears to exhibit failure of osseointegration on the control side (OSFE), with a large space present at the implant–bone interface. Nevertheless, there was considerable formation of new bone surrounding the other implants with the osteocytes in parallel array forming lamellar bone, which indicated significantly obvious osseointegration. The newly formed bone was deposited on the surface of the bone particles, forming an extensive bridge connection with many osteoblasts and osteoclasts around the experimental (A and C) and control (B and D) implants (Figure 9). (A, B: at ×40 magnification, C, D: at ×200 magnification.) According to the analysis of the two independent sample t-test, there was no significant difference in the BCR between the two methods (Table 3).
Enhanced osteogenic activity and antibacterial ability of manganese–titanium dioxide microporous coating on titanium surfaces
Published in Nanotoxicology, 2020
Quan-Ming Zhao, Yu-Yu Sun, Chun-Shuai Wu, Jian Yang, Guo-Feng Bao, Zhi-Ming Cui
Osseointegration involves both the formation and maintenance of bone at implant surfaces, and it also forms the basis for achieving biological fixation. For effective osseointegration, it is important to resolve any issues related to the implant–bone interface (Ahn et al. 2018). To achieve this, it is mandatory for implant materials to possess a diverse set of surface properties, as they directly affect osseointegration. Several studies have reported that Mn ions generated upon Mn degradation in vivo can promote the deposition of Ca and P, and local Mn-rich environment can promote the adhesion and proliferation of osteoblasts and stimulate the generation of bone callus at the fracture site (Miola et al. 2014).Our results demonstrate that the Mn–TiO2 coating induced new bone tissue formation and promoted osseointegration. The surface degradation of Mn–TiO2 coatings can release a large number of Mn ions, which can stimulate local adhesion, proliferation, and differentiation of osteogenesis-related cells, thus promoting osseointegration. This result is consistent with other findings reported in the literature.