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Role of Medicinal Plants in the Treatment of Hemorrhoids
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Yaw Duah Boakye, Daniel Obeng Mensah, Eugene Kusi Agyei, Richard Agyen, Christian Agyare
In Iran, gum resins of Boswellia serrata Roxb. ex Colebr. and B. carterii Bird. have been used for the management of hemorrhoids for all age groups.7 The gum resins from Boswellia species mainly contain boswellic acid; a mixture of tetracyclic triterpenes and pentacyclic triterpenes are reported to be responsible for its anti-inflammatory effect.18 In a study done on boswellic acid, it was observed that these acids are specific, non-redox inhibitors of leukotriene synthesis either by interacting immediately with 5-lipoxygenase (5-LOX) or restricting its translocation and thus acting as anti-inflammatory agent.49 Al-Harrasi et al.2 used formalin-induced pain and acetic acid-induced writhing to investigate the analgesic activity of B. sacra in mice. They observed that polar subfraction of B. sacra had the highest analgesic activity, almost double of aspirin (control treatment). The study proposed that Boswellia seems to produce an antinociceptive effect by both peripheral and central mechanism.2
Crohn's Disease
Published in Charles Theisler, Adjuvant Medical Care, 2023
A randomized, double-blind controlled study comparing Boswellia serrata extract H15 with mesalamine in patients with Crohn’s disease demonstrated no statistical difference in the Crohn’s Disease Activity Index, indicating Boswellia serrata is as effective as mesalamine.14 Other studies have shown possible effectiveness of Boswellia serrata gum resin in patients with ulcerative colitis. Proposed mechanisms of effect of Boswellia serrata include inhibition of 5-lipoxygenase.15
Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Sarwar Beg
The bark of Boswellia (family Burseraceae) having sweet, cooling, and tonic effect and contain boswellic acid resin as the main chemical constituent and it’s 13-form has anti-inflammatory and anti-arthritic activities. Commonly Boswellia is useful in fever, cough, asthma, urethrorrhea, diaphoresis, convulsion, chronic laryngitis, and jaundice and is analgesic, antihyperlipidemic, and anti-atherosclerotic (James et al., 1991). In both adults and children with RA experienced effective relief from the symptoms when treated with Boswellia, despite having responded poorly in the past to standard therapies such as (NSAIDs) (Kimmatkar et al., 2003). In an animal study, Boswellic acid show significantly reduced in the infiltration of leukocytes in the knee joint and in turn, significantly reduced inflammation (Kimmatkar et al., 2003). A clinical study was conducted to assess the efficacy, safety, and tolerability of Boswellia serrata (BS). BS extract was given to the 30 patients of arthritis, 15 each receiving active drug or placebo for 8 weeks founds decrease in knee pain, increase knee flexion, and a decrease in the frequency of swelling in the knee joint (Anthoni et al., 2003).
Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome
Published in Expert Opinion on Pharmacotherapy, 2020
Akhil Munjal, Bhavtosh Dedania, Brooks D. Cash
Boswellia serrata is a moderate to large-sized branching tree that grows in dry mountainous regions of India, Northern Africa, and the Middle East. An oleo-gum resin is derived through trunk tapping after which oil content is separated from the resin. Gum-resin extracts of Boswellia serrata contain monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and pentacyclic triterpenic acids and have been used in folk medicine for centuries to treat various chronic inflammatory diseases. In murine studies, a significant reduction in lipid peroxidation, nitric oxide levels, and inducible nitric oxide synthase (markers of inflammation) was seen in subjects receiving Boswellia serrata extract (BSE) [51]. Interestingly, in a small (n = 31) double-blindplacebo-controlled multicentre trial of BSE on quality of life, symptoms, and histology in patients with collagenous colitis, it was found that the rates of clinical remission were higher in the BSE treated group at the end of 6 weeks, but there was no change seen in histology and quality of life [52].
The effects of Olibanum on oxidative stress indicators, cytokines, brain derived neurotrophic factor and memory in lipopolysaccharide challenged rats
Published in Toxin Reviews, 2022
Narges Marefati, Farimah Beheshti, Amin Mokhtari-Zaer, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mahmoud Hosseini
More than 200 constituents have been known in Boswellia Serrata resin (Camarda et al.2007b). It has been suggested that the strong anti-inflammatory properties of Olibanum can be attributed to the two main substances, boswellic acid and incensol acetate (Weber et al.2006, Moussaieff et al.2012b). Boswellic acid leads to inhibition of human leukocyte elastase and I kappa B kinase (IκB kinase, IKK) which is involved in the inflammatory response (Weber et al.2006). Also, incensol acetate is able to reduce inflammatory mediators, inhibition of expression of TNF-α, IL-1β and nuclear factor-kappa B (NF-κB) (Moussaieff et al.2012b). However, all of these mechanism(s) and the contribution of the components are need to be evaluated in the future.
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial
Published in Pharmaceutical Biology, 2022
Yves Henrotin, Yvan Dierckxsens, Gaëlle Delisse, Nathalie Maes, Adelin Albert
Recently, particular attention has been given to Curcuma longa L. (Zingiberaceae) and Boswellia serrata Roxb. (Burseraceae) extracts. The efficacy and safety of these extracts have already been established in several clinical trials and are known to have potent anti-inflammatory and analgesic effects in chronic conditions such as osteoarthritis (Bannuru et al. 2018). Curcumin (diferuloylmethane) is the principal curcuminoid extracted from the Curcuma longa root and is known as a powerful antioxidant. Boswellic acids, the main active ingredients of Boswellia serrata gum, are known to inhibit the 5-lipooxygenase (LOX) pathway, which is a primary source of pro-inflammatory leukotrienes. Curcumin and boswellic acids also have inhibitory effects on the nuclear factor κB (NF-κB) signalling pathway and its gene products, some of which are directly involved in the inflammatory processes and connective tissue extracellular matrix degradation (Henrotin and Mobasheri 2018; Kim et al. 2020). Both Curcuma longa and Boswellia formulations have been shown to counteract decreases in glycosaminoglycan levels and impede the secretion and activity of matrix Metalloproteases (MMPs), which could potentially forestall further degradation of connective tissue. In summary, many in vitro studies suggest that Curcuma longa and Boswellia serrata could provide a therapeutic benefit that extends beyond symptom relief to disease modification. Two recent meta-analyses evaluating a large number of dietary supplements ranked Curcuma longa and Boswellia serrata among the most effective compounds for pain reduction in OA at the short term although the quality of evidence was low (Bannuru et al. 2018; Liu et al. 2018). Altogether, these elements give a good rationale to combine Curcuma longa and Boswellia serrata to relieve joint discomfort in hand OA.