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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
The name ginseng is used in reference to several plants of the genus Panax, i.e., Panax ginseng, or Korean ginseng; Panax notoginseng, or Chinese ginseng; and Panax quinquefolius, or American ginseng. The herb called Siberian ginseng is not in the Panax family, but is rather another plant entirely, Eleutherococcus senticosus. Ginseng has been used for several thousand years in Asia as a tonic and in TCM has been included as an ingredient in several classical herbal combinations for the treatment of MDD. It is currently classified by many as an adaptogen, with the alleged ability to enhance physical performance, promote vitality, increase resistance to stress and aging, and strengthen immune function.
Chemical Constituents of Ginseng Plants
Published in Joseph P. Hou, The Healing Power of Ginseng, 2019
Panax notoginseng is a species of the genus Panax, and it is most commonly referred to in English as notoginseng. In Chinese it is called tiánqī ( ), tienchi ginseng, sānqī ( ) or sanchi, “three-seven root,” and “mountain paint.” Notoginseng belongs to the same scientific genus as Asian ginseng. In Latin, the word panax means “cure-all,” and the family of ginseng plants is one of the best-known herbs.
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Aqueous solution of Panax notoginseng (Burkill) F.H. Chen ex C.H. Chow given orally at a daily dose of 12 mg/kg to ApoE deficient C57BL/6L mice on high-fat diet for 8 weeks reduced the development of atherosclerotic lesions from 8.7% to 2.9%.239 This supplementation evoked a reduction of total cholesterol from 1051.5 to 861.8 mg/dL, low-density lipoprotein from 726.8 to 577 mg/dL and lowered high-density lipoprotein from 308.8 to 263.1 mg/dL.239In vitro, this extract at a concentration of 300 μg/mL lowered the tumor necrosis factor-α-induced adherence of monocytes to coronary artery endothelial cells by about 25%.239 The extract at a concentration of 300 μg/mL inhibited the tumor necrosis factor-α-induced expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 by coronary artery endothelial cells.239
Nephrotoxicity induced by natural compounds from herbal medicines – a challenge for clinical application
Published in Critical Reviews in Toxicology, 2022
Jinqiu Rao, Ting Peng, Na Li, Yuan Wang, Caiqin Yan, Kai Wang, Feng Qiu
Compatibility refers to the combined application of HMs to produce a certain synergistic effect or detoxification effect. Under the guidance of the theory of HMs (Shiba Fan and Shijiu Wei), the incompatibility of prescriptions should be avoided. For example, glycyrrhizic acid mitigated the cytotoxic effect of AA and ameliorated the inhibitory effect of AA on the proliferation of renal tubular epithelial cells (Zhang and Zhang 2003; Mohamed et al. 2016). Yishen Ruanjian powder treated with rats revealed the levels of TGF-β1, connective tissue growth factor, as well as tissue inhibitor of metalloproteinase 1 induced by sodium aristolocholate salt surface were decreased, hence, the effect of AAs on renal fibrosis was antagonized (Fang et al. 2004). Secondly, HMs with calcium antagonism (Chen et al. 2005) were used to inhibit calcium influx from epithelial cells on renal tubules, counter the effect of AAs on increasing intracellular free calcium ion concentration, and prevent apoptosis of renal tubular epithelial cells. Total glucosides of paeoniae reduced renal toxicity by down-regulating the expression of TGF-β induced by TP. In addition, panax notoginseng can significantly decrease the dissolution of TP and reduce its toxicity to the kidney (Song and Fang 2021).
The transnational move of interdisciplinarity: Ginseng and the beginning of neuroscience in South Korea, 1970–1990s
Published in Journal of the History of the Neurosciences, 2022
Studies on herbs—particularly ginseng—received much attention from the government in the 1970s, as herbs had become promising candidates for export. Under the authoritarian regime of Chung-Hee Park (1963–1979), increasing exports was touted as “the only way for Korea to survive” (Kim 2017; Lee et al. 2005; The Editorial Board 1997). The government was committed to finding and “exporting whatever [we] can sell” (Park 2014). Textiles, wigs, and plywood were the most popular exports in the 1960s. The government celebrated the increase of export from U.S. $25 million in 1956 to U.S. $100 million in 1964, designating November 30 of that year as the First Memorial Day of Export. In this milieu, from the mid-1960s, ginseng was spotlighted as an important export item to be developed. There were several types of ginseng: for example, American ginseng (Panax quinquefolius), South China ginseng (Panax notoginseng), and Korean ginseng (Panax ginseng), depending on cultivation areas. It was therefore important for South Korea to differentiate its ginseng from others and to promote Korean ginseng’s distinctive effects and strengths (Park et al. 2014, 126). To this end, the government invested in various research projects to increase the competitiveness of Korean ginseng as an export.
Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Lei Wang, Jianwei Xu, Ye Yan, Han Liu, Feng Li
Nanoparticles from plants could be more beneficial since it does not need complicated processes such as intracellular synthesis and numerous decontamination steps [15,16]. Panax notoginseng is an extremely cherished ginseng species in genus Panax, Araliaceae family [17]. Panax notoginseng is considered as a medication for averting blood loss and recovering from injury and also used broadly in the form of foods or drugs. This species is used in Chinese traditional medicine, which possesses the capacity to protect liver injury that was induced by D-galactosamine in mice [18]. Panax notoginseng and its active components seem to be efficient against colorectal cancer [19,20]. Ethanol extracts of Panax notoginseng also restrain spleen tumour and liver metastasis [21]. Previous reports have shown that Panax notoginseng extracts are effective against skin, lung, prostrate and liver cell lines [22–25].