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The Role of Plant-Based Natural Compounds in Inflammation
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Marcela Dvorakova, Premysl Landa, Lenka Langhansova
In Morus alba L., a herbal plant with anti-inflammatory properties, another prenylated flavonoid was found in large amounts in the roots. This flavonoid, cudraflavone B, inhibited several pro-inflammatory enzymes, including cyclooxygenases. Its inhibitory activity with IC50 values of 1.5 µM and 2.5 µM for COX-1 and COX-2, respectively, was similar to that of indomethacin (IC50 = 0.3 µM and 1.9 µM for COX-1 and COX-2, respectively) (Hosek et al., 2011). In addition, cudraflavone B was mentioned as an effective 5-LOX inhibitor (54% inhibition at 10 µM concentration) in a diploma thesis of Glibo (2016); however, no further information was available (Glibo, 2016).
1,3-Diphenyl-2-Propene-1-One-Based Natural Product Antidiabetic Molecules as Inhibitors of Protein Tyrosine Phosphatase-1B (PTP-1B)
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Vivek Asati
Chalcone, (E)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl) phenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one (25) was isolated from the root bark of Morus alba L. along with 21 phenolic compounds. The chalcone exhibited a notable PTP-1B inhibition with an IC50 value of 31.61 μm in a noncompetitive manner.51
Pharmacological Properties of Mulberry (Morus Alba)
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Morus alba L. (white mulberry) usually originated from Asia and is used for sericulture in India, China, Vietnam, and Korea. It is also known as the “folk sacred fruit”. The mulberry trees have been extensively scattered throughout the world representing different species, which are native to other countries, such as America, Arabia, China, India, Japan, North Africa, South Europe, and Taiwan etc. It is a medium sized tree about 30 m in height and monoecious or deciduous tree with large stems bearing bark. This species is indigenous to China and is also found in hilly areas of Himalayas. This species has been used in China as a remedy to various diseases.
Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage
Published in Biomarkers, 2022
Mai M. Farid, Asmaa F. Aboul Naser, Maha M. Salem, Yomna R. Ahmed, Mahmoud Emam, Manal A. Hamed
In the current study and in agreement with the results of Akbarzadeh et al. (2007) and Hussein et al. 2012), the diabetic rats showed an elevation in the blood glucose and α-amylase levels, as well as a significant drop in insulin levels. Treatment with Commiphora opobalsamum butanol fraction improves BGL, insulin and α- levels as compared with the reference drug; Glibenclamide. These results was confirmed by the observation of Jäger et al. (2009) who sated that the secondary metabolites present in leaves, seeds, fruits, and plant roots as triterpenes and phenols had anti-diabetic effect and exert its action through the anti-diabetic pathways. By inhibiting α-amylase, α-glucosidase, and pancreatic lipase; triterpenes can block enzymes in the glucose metabolism pathway and reduce insulin resistance as well as the plasma glucose level (Oboh et al. 2021). Assiri et al. (2017) added that the mechanism of antidiabetic action of the bioactive compounds in Morus alba are involve in the intracellular pathways of insulin signalling or glucose homeostasis.
Mulberry fruit improves memory in scopolamine-treated mice: role of cholinergic function, antioxidant system, and TrkB/Akt signaling
Published in Nutritional Neuroscience, 2021
Suk Kyung Shin, Jae-Myung Yoo, Fu Yi Li, Seong Yeon Baek, Mee Ree Kim
Mulberry fruit, the fruit of Morus alba L., has some beneficial properties, such as anti-allergy [11], antioxidant, and anti-diabetes [12]. The biological actions of mulberry fruit are closely related with various phytochemicals, such as anthocyanins [13], polysaccharides [14], phenolic acids [15], and flavonoids [11]. Recently, it was reported that the antioxidant activity of an ethyl acetate fraction of mulberry fruit extract (MFE) was stronger than that of other solvent fractions, such as those of hexane, chloroform, n-butanol, and water as well as that of a 70% ethanol extract [12]. In addition, ethanol extract of mulberry fruit, which is rich in anthocyanins, has been reported to exhibit potent neuroprotective actions [16–18]. Although the antioxidant activity of MFE is stronger than that of an ethanol extract of mulberry fruit, there is no report concerning protection of neuronal cells against oxidative stress-mediated neurodegeneration.
Natural options for management of melasma, a review
Published in Journal of Cosmetic and Laser Therapy, 2018
Mulberry extract is a Morus alba L. derivative plant from Moraceae family. The root bark has been found to have skin depigmenting effects due to its inhibitory action of dopa oxidase activity of tyrosinase and its superoxide scavenging activity (53). An in vitro investigative study looked at the effects of compounds found in dried mulberry leaves on melanin biosynthesis (79). The result of this study was significant as cultured melan-a cells responded positively. It was discovered that dried mulberry leaves have an inhibitory effect on tyrosinase action and on melanin formation in melan-a cells (79). A randomized clinical trial investigated 75% topical mulberry oil compared to a placebo in the treatment on melasma (80). Results demonstrated that mulberry was a safe and effective lightening agent with added antioxidant benefits with mild side effects such as itching (Table 3).