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Cancer
Published in Spyridon E. Kintzios, Maria G. Barberaki, Evangelia A. Flampouri, Plants That Fight Cancer, 2019
These include diverse, mostly controversial methods for treating cancer while avoiding the debilitating effects of conventional methods. The alternative treatment of cancer will probably gain in significance in the future, since it has been estimated that roughly half of all cancer patients currently turn to alternative medicine. The most prominent alternative cancer treatments include: The delivery of antineoplastons, peptides considered to inhibit tumor growth and first identified by Stanislaw Burzynski in blood and urine. According to the Food and Drug Administration (FDA) the drug can be applied only in experimental trials monitored by the agency and only on patients who have exhausted conventional therapies. However, the therapy has found a significant amount of political support, while attracting wide publicity.Hydrazine sulfate, a compound reversing cachexia of cancer patients, thus improving survival.Various herbal extracts, some of which are dealt with in this book.
Tumor Necrosis Factor
Published in Andrzej Mackiewicz, Irving Kushner, Heinz Baumann, Acute Phase Proteins, 2020
Peter G. Brouckaert, Claude Libert
Consequently, we tried to identify the systems or proteins involved in this protection. A possible involvement of glutathione transferases or P450 cytochromes was excluded, since these are downregulated by IFN and IL-1, respectively. APPs, however, are strongly induced by IL-1 in C57B1 mice.74 Since IL-6 is the most potent inducer of APPs, we tried to induce desensitization with IL-6, murine or human, in various doses and according to several regimens, in both the presence and absence of glucocorticoids, but failed to observe any protective effect.97 This result, together with our unpublished observation that IL-1-induced protection was also observed in adrenalectomized mice, does not suggest an involvement of APPs. In another study, protection against the same lethal events was induced by hydrazine sulfate, but not in hypophysectomized mice.98 Recently, a Japanese group found that IL-1-induced desensitization to bacterial infections and LPS could be explained by a faster clearance of LPS in the desensitized mice,99 but we found no changed kinetics of TNF after injection in IL-l-vs. PBS-treated mice.97 Obviously, considerable differences exist between TNF and LPS as a challenge, as some globins (e.g., α1-AGP and α1-PI), inducible by IL-1, are known to suppress the release of LPS-induced TNF from leukocytes.100 Indeed, α1 PI protects mice against a lethal challenge of LPS + GalN because of suppressed TNF release.101 These findings easily explain the often elevated serum TNF levels in alcoholic cirrhosis.102
Oncology
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
Alternative treatments utilize physiological and psychological therapies to strengthen the immune system. Antineoplastin therapy is based on the theory that the body has a parallel biochemical defense system (BDS) that is independent of the immune system and can help reprogram defective cancer cells to begin normal functions. These polypeptides are given in synthetic form in treatment of lymphoma, leukemia, and several other types of cancers. Botanical medications utilized successfully include shiitake and maitake mushrooms (to stimulate immune function), shark cartilage (an anti-angiogenic that inhibits blood supply in tumors), shark liver oil (to generate antibody response), and hydrazine sulfate (to treat cachexia). Nutritional and vitamin therapies, emotional and sociological support, visualization, and biopsychosocial programs (e.g., Block's) are also utilized, as is traditional Chinese medicine in the form of acupuncture, herbs, meditation, and exercise therapies.
Current advancements in pharmacotherapy for cancer cachexia
Published in Expert Opinion on Pharmacotherapy, 2023
Guilherme Wesley Peixoto da Fonseca, Ryosuke Sato, Maria Janieire de Nazaré Nunes Alves, Stephan von Haehling
Since the proposed used of corticosteroids [11] and hydrazine sulfate [12–14], the first two anti-anorexia/cachexia agents emerged in the mid-1980ʹs to treat cachexia, until the new promising monoclonal antibody was developed to work through blocking circulating human growth differentiation factor 15 (GDF15; NCT05546476), the pharmacotherapy of cancer cachexia has evolved from only increasing appetite and caloric intake with no changes in body composition [15] to compounds able to increase body weight via improving lean body mass (LBM) and fat mass [16] (Figure 1). However, we are still lacking an improvement in muscle function and muscle strength, an independent prognosis factor in patients with cancer cachexia [17], as well as outcomes related to better survival.
Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Shaoyong Ke, Zhigang Zhang, Manli Liu, Wei Fang, Daye Huang, Zhongyi Wan, Ronghua Zhou, Kaimei Wang, Liqiao Shi
According to the above aforementioned, in order to explore the possible structure-activity relationship, the available diasteromers (epiandrosterone and androsterone) were selected to construct two series of novel steroidal isatin derivatives (3a–h and 6a–h). Firstly, the corresponding epiandrosterone or androsterone was treated with hydrazine hydrate under the catalytic condition of hydrazine sulfate to obtain the intermediates 2 and 5. Then the compounds 2 or 5 was condensed with various substituted isatin to the target steroidal isatin conjugates 3a–h or 6a–h. All the target derivatives were characterized by 1H NMR, 13C NMR, and ESI-MS spectroscopic analyses.
Calcium alginate nanoparticle crosslinked phosphorylated polyallylamine to the controlled release of clindamycin for osteomyelitis treatment
Published in Drug Development and Industrial Pharmacy, 2021
Murugesan Gowri, Nachimuthu Latha, Kannan Suganya, Marudhamuthu Murugan, Mariappan Rajan
EPS assay was done to quantify and compare the sum of exopolysaccharides present in the drug-treated and untreated biofilms of E. cloacae. The biofilms were developed, as stated above. The free-floating cells were removed, and the film was washed with 500 μL PBS. The entire suspensions in PBS were transported to fresh sterile test tubes, and an equal volume of 5% phenol was added to the cell suspension. H2SO4 5 ml supplemented with hydrazine sulfate 0.2% was added further, and the entire mixture was incubated in the dark for 1 h. After incubation, the absorbance was measured at 490 nm.