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Endangered Medicinal Plants of Temperate Regions: Conservation and Maintenance
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Coptis teeta is a small perennial herb with the height of 20-25 cm. It is popularly known as Coptis or Mishrni tita and is an important medicinal plant used against various diseases. The explicit nomenclature `Tita’ has been come out for its bitterness. Its tenuous rhizome, known as “Yunnan goldthread” in the traditional Chinese medicine (TCM) system, has been used as an antibacterial and as an anti-inflammatory medicine for a long time (Mukherjee and Chakraborty, 2019). This has a compound leaf, serrated into three parts; the leaf blade is ovate, triangular in shape. Length of the leaf varies from 5-13 cm and breadth 4-9 cm. Leaf is papery in nature. Lateral segment subsessile to petiolate, shorter than the central, serrated leaf, unequally parted. Central segment is petiolate, pinnately divided. Leaf margin is acute, apex attenuate, scales 15-26 cm tall, glabrous. Base of the leaf is cordate. Root is fibrous with small yellow-colored. The color of the rhizome is golden yellow. Inflorescence is cymose, and root is a pungent, very bitter, cooling herb that controls bacterial and viral infections, relaxes spasms, lowers fevers and stimulates the circulation (Mukherjee, 2018b). The root contains several compounds that are effective in inhibiting various soil-inhabiting microbes, mainly bacteria and are a safe and effective treatment for many ailments, such as some forms of dysentery that are caused by bacteria (http://en.wikipedia.org/wiki/Coptis_teeta).
Botanicals and the Gut Microbiome
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Coptis chinensis is traditionally used in traditional Chinese Mmedicine and contains berberine, an isoquinoline alkaloid, which has shown an effect with non-alcoholic fatty liver disease (NAFLD), through the increase in the abundance of bacteria associated with metabolic improvements such as those from Bacteroidetes, Bifidobacterium and Lactobacillus (Cao et al., 2016).
Antihypertensive effects of oriental drugs in human and SHR
Published in H. Saito, Y. Yamori, M. Minami, S.H. Parvez, New Advances in SHR Research –, 2020
Hideaki Higashino, Aritomo Suzuki, Koichiro Komai
Coptis chinensis Franch. (ref.A, 1990; ref.9, 1963). A major component of this plant, berberin, decreased blood pressures in anesthetized dogs, cats and rabbits, and also in conscious rats given intravenously or orally. At common or lower doses, an excitation of the heart and an increment of coronary arterial blood flow were observed, but at higher doses heart function was inhibited on the contrary. Although there were many reports related to the antihypertensive effects, both actions of direct vasodilative effect and potentiation on acetylcholine mediated hypotensive effect were generally accepted as its vasodepressant mechanism.
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study
Published in Xenobiotica, 2023
Si-cong Li, Min Zhang, Bin Wang, Xu-ting Li, Ge Liang
Coptisine (COP) (Figure 1) is a prominent alkaloid found in Coptis chinensis, a traditional Chinese medicine that exhibits various pharmacological effects. Its notable effects include the treatment of bacterial infections and anti-inflammatory (Kwon et al. 2016; Chen et al. 2017; Hu et al. 2019). In Chinese veterinary medicine, practitioners frequently combine COP-containing preparations with florfenicol to manage bacterial infections in animal intestines. However, the interaction between COP and florfenicol, particularly in terms of their mechanism of action, remains unclear. Although some studies have suggested that COP may modulate the expression or activity of P-gp or P450 enzymes, the exact nature of the interaction between COP and florfenicol requires further investigation.
Jateorhizine alleviates insulin resistance by promoting adipolysis and glucose uptake in adipocytes
Published in Journal of Receptors and Signal Transduction, 2021
Changqin Cheng, Zhiyong Li, Min Zhang, Dezhi Chen
In the traditional cognition of Chinese medicine, IR patients often present with the syndrome of interior dampness-heat in Chinese medical practice, while the cold property of coptis chinensis can remove the dampness and heat, so coptis chinensis may have a potential therapeutic effect in the treatment of IR [7]. In recent years, traditional Chinese medicine studies have found that coptis chinensis is the most commonly used compound compatibility drug for lowering glucose [8–10]. Coptis chinensis is a perennial herbaceous plant of ranunculaceae, its rhizome has the effect of lowering blood glucose and regulating blood lipid [11], which is mainly related to the pharmacoactive ingredients in the rhizome, including berberine, palmatine, coptisine and so on [12]. Among them, berberine is the most studied rhizoma coptis alkaloid, which has the effect of improving atherosclerosis [13]. Jateorhizine (Jat) is a homologen of berberine, which is also a tetrahydroisoquinoline alkaloid with the similar chemical structure to berberine. Animal experiments have shown that Jat can lower blood glucose level in diabetic mice [14,15]. However, there are few studies on the role of Jat in IR, and the specific mechanism of its hypoglycemic effect is still ambiguous.
Characterization of hydrocoptisonine metabolites in human liver microsomes using a high-resolution quadrupole-orbitrap mass spectrometer
Published in Xenobiotica, 2020
Su Min Choi, Younah Kim, Jaeick Lee, Ju-Hyun Kim, Taeho Lee, Byung Sun Min, Jeong Ah Kim, Sangkyu Lee
Coptis chinensis belongs to the Ranunculaceae family and is one of the most widely used traditional Chinese medicines. It has attracted much attention because of its multiple pharmacological effects, such as anti-antiviral, anti-inflammatory, and anti-microbial activities, and its ability to dry dampness, treat toxicosis, and detoxify (Commission CP, 2015; Hwang et al., 2006; Lee et al., 2018; Miao et al., 2015; Yu et al., 2005). Hydrocoptisonine is a new protoberberine-type compound isolated from the rhizomes of C. chinensis by our group, previously (Cao et al., 2018) (Figure 1). Although there is no data directly reporting the pharmacological effects of hydrocoptisonine itself, as a newly identified compound, its pharmacological activity will be determined in the future.