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Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Due to its exotic flavor and hot taste, cinnamon is used as a culinary spice and also a traditional medicine since antiquity. In traditional medicine, cinnamon is used in the treatment of respiratory and digestive ailments, as a stimulant, and as an anointment since antiquity (246). Recently, many experimental and clinical trials have explored its antimicrobial, anti-inflammatory, antidiabetic, antioxidant, antilipemic, and cognition enhancer effects for the treatment of infection, diabetes, depression, hypercholesterolemia, and Parkinson’s disease (246–248). However, Cassia cinnamon (Chinese cinnamon) contains high levels of coumarins, about ten times more than Ceylon cinnamon. Coumarin is toxic to the liver in high doses. Therefore, its addition into food products is prohibited. Due to a lack of awareness regarding the standard limits of cinnamon in these products, it is advisable for patients of hepatic disorders to avoid cinnamon (246). In addition, a daily intake of coumarin more than 0.1 mg/kg body weight can lead to conspicuous effect on the blood coagulation profile if the patient is simultaneously on drugs such as warfarin. However, these results are still contradictory (246). So, it is recommended not to take a lot of pure cinnamon product or supplement. High intake of cinnamon can cause liver damage, mouth sore, cancer, hemorrhage, and breathing problems.
Introduction
Published in Brijesh Kumar, Vikas Bajpai, Vikaskumar Gond, Subhashis Pal, Naibedya Chattopadhyay, Phytochemistry of Plants of Genus Cassia, 2021
Brijesh Kumar, Vikas Bajpai, Vikaskumar Gond, Subhashis Pal, Naibedya Chattopadhyay
The pharmacological activity profile of many Cassia species is of great importance. Some of them like C. glauca C. angustifolia and C. acutifolia are included in the pharmacopeia. Some of the important activities such as antioxidant, antidiabetic, hepatoprotective activity and cytotoxic activity along with many other activities of Cassia species are shown in Table 1.3 (Safaa et al., 2019).
The Orient
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
In Greco-Roman obstetrics and gynecology, Cassia was employed to aid placental delivery and to treat inflammation of the uterus. In the seventeenth and eighteenth centuries Cinnamon was in vogue to induce menstruation, to prevent miscarriage, to avoid pregnancy sickness, induce labor, increase breast milk production, and as a medication for women’s disorders in general. Cassia bark, cortex cinnamoni, or rougui, is currendy indicated in TCM for amenorrhea, dysmenorrhea, frigidity and impotence, while the cassia twig, ramulus cassia, or guizhi, is also advocated for amenorrhea (PPRC, 1992).
Anti-diabetic and hypolipidemic effects of Cinnamon cassia bark extracts: an in vitro, in vivo, and in silico approach
Published in Archives of Physiology and Biochemistry, 2023
K. Vijayakumar, B. Prasanna, R. L. Rengarajan, A. Rathinam, S. Velayuthaprabhu, A. Vijaya Anand
The biological activity of the plant source or not depending on the single phytoconstituents, but it is may be due to the synergic effect of various phytoconstituents such as tannins, phenol, terpenoids, etc. Ahamed et al. (2003) reported that the bark extract of C. cassia contains numerous phytoconstituents such as tannins, alkaloids, saponins, and flavonoids. The present study revealed that the presence of various phytoconstituents in the bark extract of C. cassia, such as alkaloids, tannins, phenols, and terpenoids. These results are evident in the present study also. In the present study, the aqueous, methanol, and ethanol extract of C. cassia bark contains a large number of phytoconstituents when compared to the other three extracts (hexane, petroleum ether, and chloroform). Based on the results, further studies are carried out only with aqueous, ethanolic, and methanolic extract of C. cassia bark.
Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats
Published in Drug and Chemical Toxicology, 2022
K. Vijayakumar, R. L. Rengarajan, N. Suganthi, B. Prasanna, S. Velayuthaprabhu, M. Shenbagam, A. Vijaya Anand
Cinnamon cassia (C. cassia) is an important plant in the Lauraceae family widely used by people worldwide for its aroma (Hang et al.2007). Many studies have been shown that various parts of C. cassia exhibited anti-microbial (Hili et al.1997, Matan et al.2006), anti-fungal (Wang et al.2011), anti-inflammatory (Tung et al.2010), antioxidant (Prasanna and Vijaya Anand 2019), and anti-cancer (Kwon et al.2010, Lu et al.2010, Vijayakumar et al.2020) activities. However, there is limited information available on dose selection, and their protective effect on the multi-organ in diabetic conditions. Therefore, the present study aims to address the in vitro antioxidant potential, acute toxicity, and dose fixation of an ethanol bark extract of C. cassia, and its effect in the regulation of mitochondrial, hepatic marker enzymes, and renal markers in the streptozotocin (STZ)-induced diabetic rats.
Functional Food and Cardiovascular Disease Prevention and Treatment: A Review
Published in Journal of the American College of Nutrition, 2018
Sedigheh Asgary, Ali Rastqar, Mahtab Keshvari
A recent study reported the potential effects of 2 compounds, cinnamic acid and cinnamic aldehyde, isolated from C. cassia against myocardial ischemia, representing that cinnamon also has potential effects in cardiovascular disease treatment (161). Numerous studies have reported the defensive effects of cinnamaldehyde on the cardiovascular system (161,162). Cinnamophilin mainly inhibits thromboxane receptor–mediated vascular smooth muscle cell proliferation and can have the potential for use in the prevention of vascular diseases and atherosclerosis (163).