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Kidney Failure/Renal Insufficiency/Chronic Kidney Disease (CKD)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Zinc Supplementation: Subnormal plasma zinc levels and decreased zinc concentration in hair and leucocytes, as well as increased plasma ammonia and ribonuclease activity in dialyzed and non-dialyzed uremic patients, indicate that zinc metabolism is abnormal in uremia and is not corrected by dialysis. Abnormalities of taste and sexual function improved significantly in patients receiving zinc supplements, but not in those on placebo therapy. These improvements in biochemical as well as clinical parameters confirm and add to earlier observations of improvement in taste and sexual function after zinc supplementation. Together, they suggest that zinc deficiency is a complicating feature of uremia and can be corrected by oral zinc acetate supplementation.17
Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
The RDA (Recommended Daily Allowance) for zinc is 11 mg/day for adult males and 8 mg/day for adult females (4, 26). The UL (Tolerable Upper Intake Level) is estimated at 40 mg zinc/day for adults (25). Consuming too much zinc can cause zinc poisoning or acute zinc toxicity. Symptoms of zinc poisoning are gastrointestinal irritation, dizziness, vomiting, nausea, abdominal cramps, diarrhea, and headaches in the short term (4, 25–26). Excess of zinc can disrupt absorption of copper and iron, leading to immune system dysfunction in the long term. Zinc supplements are often made with zinc acetate or gluconate (25).
Neurologic disorders in pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Robert Burger, Terry Rolan, David Lardizabal, Upinder Dhand, Aarti Sarwal, Pradeep Sahota
Wilson’s disease is a very rare disorder involving disordered copper metabolism. Clinically, there is a wide variability in the age of onset as well as presentation. In children, it more commonly presents with symptoms of liver disease, but in young adults psychiatric or movement disorders tend to predominate. The clinical picture consists of liver cirrhosis, a wide variety of abnormal involuntary movements, and psychiatric illnesses. The most common treatment for this disorder is the copper chelator penicillamine, which is known to be teratogenic. Trientine is another chelating agent sometimes used, but may also be associated with fetal malformations. More recently, the therapy with zinc acetate has been shown to be effective in the treatment of Wilson’s disease (85), and a small case series suggests only a mildly elevated birth defect rate compared with the general population (86). The authors of that paper conclude that zinc acetate is a preferable treatment for Wilson’s disease in pregnant women.
Green synthesis of ZnO-NPs using endophytic fungal extract of Xylaria arbuscula from Blumea axillaris and its biological applications
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2023
Lavanya Nehru, Gayathri Devi Kandasamy, Vanaraj Sekar, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Abdulrahman Alasmari, Preethi Kathirvel
Presently, green synthesis of NPs is in high demand due to its extensive application in biomedicine, eco-friendliness, and cost-effectiveness. Therefore, the study was aimed at investigating the endophytic fungi-mediated fabrication of ZnONPs utilising Xylaria arbuscula (MN904863) isolated from Blumea axillaris Linn. as a capping agent and zinc acetate (Zn (CH3COO)2 2H2O) as a precursor salt. To the best of our knowledge, this is the first report that attempts to figure out the potent biological activities of ZnONPs fabricated employing the endophytic fungal extracts of Xylaria arbuscula. Characterising the mycogenically synthesised ZnONPs using UV–Vis spectroscopy, FT-IR, SEM, XRD, TEM, DLS, EDX, and Zeta Potential is another crucial objective. Finally, biofabricated nanoparticles were evaluated for their potential biological activities, including antimicrobial activity against pathogenic bacteria and fungi, as well as their in vitro antidiabetic, anti-inflammatory, cytotoxic, and wound healing efficacy for their myriad applications in biomedicine.
Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro and in vivo study
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2022
Badriyah Alotaibi, Walaa A. Negm, Engy Elekhnawy, Thanaa A. El-Masry, Mohamed E. Elharty, Asmaa Saleh, Dalia H. Abdelkader, Fatma Alzahraa Mokhtar
ZnO-NPs were produced utilising GTME, as described by Attia et al with minor modifications [37]. The GTME (1 g) dissolved in ethyl alcohol (100 ml) was allowed to react with zinc acetate (10 g), mixed in doubly distilled water (D.W.) (1 L), and heated in a boiling water bath for 30 min to produce ZnO-NPs, the reaction mixture temp. was adjusted at 70°C. The pH was then raised to 11 by adding 0.1 M sodium hydroxide (only a few drops), resulting in the formation of a white precipitate of ZnO-NPs. For complete reduction of zinc acetate to ZnO-NPs, the mixture was set for an hour at room temp. The produced ZnO-NPs were centrifuged at 4000 rpm for 10 min, then washed three times with D.W. and three times with ethanol to yield a 900 mg white powder of ZnO-NPs after freeze-drying. Characterisation of the formed ZnO-NPs was displayed in Supplementary data.
The effective photocatalysis and antibacterial properties of AgBr/Ag2MoO4@ZnO composites under visible light irradiation
Published in Biofouling, 2019
Huihui Xu, Jie Zhang, Xianzi Lv, Tianjie Niu, Yuxiang Zeng, Jizhou Duan, Baorong Hou
In a typical procedure for the preparation of ZnO samples, 0.8299 g of zinc acetate were dissolved in 60 ml of water, sonicated for 5 min and stirred continuously to obtain a clear solution at room temperature. Then, 6 ml of aqueous NaOH (4 M) solution were slowly added dropwise into the above solution under stirring at room temperature, and the pH of the solution was adjusted to 12. After that, the solution was stirred continuously for 30 min until a white colloidal solution was obtained. The solution was transferred into a 100 ml Teflon-lined stainless steel autoclave, which was heated to 120 °C for 8 h (Li et al. 2017; Cheng et al. 2018; Liu et al. 2019). Then, the products were cooled to room temperature and collected after filtering and washing with water and ethanol. Finally, the white samples were dried at 60 °C in a vacuum oven for 12 h to obtain pure ZnO crystals (Mahsa and Aziz 2017).