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Nutritional nuts and bolts
Published in Rachel Pryke, Joe Harvey, Annabel Karmel, Weight Matters for Children, 2018
Rachel Pryke, Joe Harvey, Annabel Karmel
E-numbers form the European classification that is used to identify all additives that go into foods. All of these additives undergo testing to ensure they are safe for people to eat (but not everyone agrees with the conclusions of some of these safety committees).
The safety and quality of food
Published in Geoffrey P. Webb, Nutrition, 2019
E numbers, have been used for many years to designate food additives in Britain and the rest of the EU. They were introduced as part of efforts to harmonise legislation within the EU and to overcome language barriers. They were originally envisaged as something that would help to engender consumer confidence. If an additive had an E number, the consumer could be totally assured of its safety. In reality however, the effect was quite the opposite, E numbers on food labels evoke suspicion and have been used to epitomise everything that is unwholesome about “modern, adulterated and artificial food”. Several nutrients and compounds that would be familiar (and perhaps less threatening by name) have been given E numbers: E101 is riboflavin E300 is vitamin C E302 is calcium carbonate E307 is vitamin E E120 is cochineal E140 is chlorophyllE150 is caramel E160a is carotene E260 is acetic acid (vinegar) E553b is talc E901 is beeswax
Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera
Published in Hematology, 2023
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori
PB-MNCs of JAK2V617F positive PV patients treated with enalaprilat showed a significant reduction in BFU-E number at every dose tested. (Figure 3(A)). The number of CFU-GEMM decreased significantly with respect to controls only at 1μg/ml of enalaprilat (Figure 3(A)). Instead, treatment with losartan caused a significant reduction of BFU-E number only at high doses (1 and 10 µg/ml) (Figure 3(B)). CFU-GM did not show any significant change with both drugs, except for 1 µg/ml enalaprilat concentration in which GM number increased (Figure 3(A,B)). We tested also samples isolated from BM of PV patients. In these cells, BFU-E frequency decreased only at the lowest dose of enalaprilat (Figure 3(C)) and 0.1 and 1 µg/ml losartan (Figure 3(D)). No differences were observed in GEMM and GM colonies with both drugs, except for GEMM reduction with 0.01 µg/ml losartan. The reduction in erythroid colony number observed in PB samples correlates with the reduction in total colony number with both drugs, except at 1 µg/ml enalaprilat (Figure 3(E)). In BM samples, this correspondence is not present, probably due to higher variability in GEMM and GM counts (Figure 3(F)).
Measurement of barriers to perform periodic examinations: development and psychometric properties scale
Published in International Journal of Occupational Safety and Ergonomics, 2023
Hossein Akbari, Mitra Hannani, Masoud Motalebi Kashani, Marzie Sadaf, Hamid Reza Saberi, Sedighe Dehghani Bidgoli, Fahimeh Karamali
To determine the content validity, first, a questionnaire was given to 13 experts, six of whom were active occupational health experts with at least a bachelor's degree and 5 years of working experience in the industry, one an occupational medicine specialist and six faculty members of the Occupational Health Engineering Department with a Ph.D. degree. The experts first assessed each question in terms of necessity. The necessity of each question was measured using a 3-point Likert scale, including ‘necessary and useful’, ‘useful and unnecessary’ and ‘non-useful’, based on the content validity ratio (CVR) [16] calculated using Equation (1): ne = number of experts who selected the necessary and useful option; N = total number of experts.
3-Dimensional nano-fibre scaffold for ex vivo expansion of cord blood haematopoietic stem cells
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Seyed Hadi Mousavi, Saeid Abroun, Masoud Soleimani, Seyed Javad Mowla
The CFU-G/GM number represents the number of haematopoietic stem/progenitor cells with the capacity to differentiate into myeloid cells and the BFU-E number reflects the potential of haematopoietic stem/progenitor cells to develop into erythrocytes, both of which are important for the engraftment of human stem cells in transplantation. Our data suggest that our 3D culture system enhances the myeloid lineage amplification better than the erythroid lineage. In this experiment, the CFU-G/GM of the amplified cells increased significantly after 12 days’ culture in the 3D system, whereas the BFU-E number decreased in both the 2D and 3D culture systems at day 12. Similar data regarding the change in BFU-E levels have also been reported in the collagen bead 3D culture system [21]. One explanation for the lower BFU-E number is that in both 3D culture systems the cytokine EPO was absent [27].