Explore chapters and articles related to this topic
Preclinical Antidepressant-Like Effects of Terpenes, Polyphenolics, and Other Non-Flavonoid Phytochemicals
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Ellagic acid is a polyphenolic compound found in a variety of herbs, including Quercus rubus, Euphorbia antisyphilitica, Quercus alba, Rubus idaeus, and Rubus occidentalis.64 It is also common in a variety of nuts, fruits, and vegetables. It possesses potent neuroprotective effects through its free radical scavenging properties, iron chelation, activation of different cell signaling pathways, and mitigation of mitochondrial dysfunction.65 It also exerts potent anti-inflammatory effects.66
Impact of Dietary Polyphenols on Arterial Stiffness
Published in Catherina Caballero-George, Natural Products and Cardiovascular Health, 2018
Tess De Bruyne, Lynn Roth, Harry Robberecht, Luc Pieters, Guido De Meyer, Nina Hermans
Black raspberry (Rubus occidentalis) extract (750mg/d; 12 weeks) improved arterial stiffness and vascular endothelial function in patients with metabolic syndrome, and inflammatory cytokines IL-6 and tumor necrosis factor-α (TNF-α) were decreased (Jeong et al., 2014, 2016).
Effects of Black Raspberries and Their Constituents on Rat Prostate Carcinogenesis and Human Prostate Cancer Cell Growth In Vitro
Published in Nutrition and Cancer, 2020
Jillian N. Eskra, Alaina Dodge, Michael J. Schlicht, Maarten C. Bosland
The use of dietary agents has long been considered an appealing approach to cancer prevention. Numerous laboratory studies have reported anticancer activity of various dietary constituents and phytochemicals, supporting the concept that increased consumption of bioactive compounds through dietary modification or supplementation can reduce cancer incidence (2). For supplements based on black raspberries (BRB; Rubus occidentalis) there is an increasing amount of evidence in support of their chemopreventive potential. BRB preparations and extracts can inhibit in vitro cancer cell proliferation, induce apoptosis, and inhibit angiogenesis (3). The most compelling evidence supporting the use of BRBs as a chemopreventive agent has been demonstrated in studies of gastrointestinal (GI) cancers (4). Dietary administration of BRBs inhibited tumor initiation as well as tumor promotion-progression in the esophagus and colon in animal models of carcinogenesis (5–8). Oral administration of BRBs also inhibited mammary carcinogenesis and bladder xenograft tumor growth in animal models (9–12), suggesting that biologically active berry constituents are systemically bioavailable following oral administration and have the ability to reach a distant tumor site. Additionally, BRBs were well tolerated and had protective effects against GI tumors in several human clinical trials (13).