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Role of Plant-Based Anti-HIV Agents in HIV-Associated Neurocognitive Disorders (Hand)
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Vishal K. Singh, Himani Chaurasia, Richa Mishra, Ritika Srivastava, Vivek K. Chaturvedi, Ramendra K. Singh
Lymphocytic propagation is persuaded through phyto haemagglutinin-induction and prolonged supervision of polyphenol-rich fruit juices, which revealed bioactivities against HIV-positive patients. The annins and subsequent phenolic derivatives have also shown virucidal impression within numerous viral organizations, such as, Lithospermic acid (Figure 2.3), which is extracted Salvia miltiorrhiza; and this acid has been effective against HIV when subjected to H9 cells [1]. Punicalagin, chebulagic acid, and punicalin have shown hydrolyzing properties and all three compounds can be obtained by Terminalia chebula showing their anti-HIV activities [44]. Repandusinic acid is extracted from Phyllanthus niruri and it demonstrates inhibitory activity against HIV-1 RTase [59].
Medicinal Plants of Central Asia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Farukh S. Sharopov, William N. Setzer
Punica granatum L. (Lythraceae) (Granat (Russian), Anor (Tajik)) is native to the Silk Road region, from Iran to northern India, but is now cultivated in desert-like habitats around the world. The peel of the fruit is used to treat skin conditions such as wounds, irritations, rashes, and dermatitis (Mamedov et al., 2004), while the fruit is eaten as a treatment for gastrointestinal diseases (Egamberdieva et al., 2013) and jaundice (Sezik et al., 2004). The juice of P. granatum contains anthocyanins and flavonoids, while the peel is rich in flavonoids and ellagitannins (punicalin, punicalagin, Figure 4.13) (Lansky and Newman, 2007).
Impact of Dietary Polyphenols on Arterial Stiffness
Published in Catherina Caballero-George, Natural Products and Cardiovascular Health, 2018
Tess De Bruyne, Lynn Roth, Harry Robberecht, Luc Pieters, Guido De Meyer, Nina Hermans
Pomegranate (Punica granatum) extract and its polyphenolic constituents punicalin, punicagalin and ellagic and gallic acid significantly suppressed AGE formation in vitro and in a mouse model (Kumagai et al., 2015). Also rambutan (Nephelium lappaceum) extract exhibited antiglycation activity in vitro, which correlated to its antioxidant activity. The main compounds were geraniin and ellagic acid (Zhuang et al., 2017). Similarly, glucitol-core containing gallotannins isolated from maple (Acer) species inhibit AGEs, mediated by their antioxidant (radical trapping) potential (Ma et al., 2016).
Anthocyanins rich pomegranate cream as a topical formulation with anti-aging activity
Published in Journal of Dermatological Treatment, 2021
Ahmed A. H. Abdellatif, Sulaiman Hamad Alawadh, Abdellatif Bouazzaoui, Ahmad H. Alhowail, Hamdoon A. Mohammed
Punica granatum L. or pomegranate is a kind of small tree native to Asia and Africa and is cultivated in different countries around the world. Secondary active metabolites such as alkaloids, tannins, polyphenolic compounds in addition to vitamins and minerals were identified in pomegranate (11–13). The bark of the plant is used as an anthelmintic agent (14), while astringent, antidiabetic and hemostatic effects were reported for all plant parts (15,16). The pomegranate plant’s parts have various biological activities that can be obtained from its extracts, for example: antimicrobial, antiviral, antioxidant, cancer preventive, anti-inflammatory, cardio-protective, and antidiabetic effects (17,18). The Chinese medicinal culture used the pomegranate’s peels to treat ulcers, trauma, hemorrhage, infections and digestive disorders for instance; dysentery and diarrhea due to its potent astringent and anti-inflammatory properties. On the other hand, Guatemala, India and Tunisia used water decoction of the peels to cure mouth infections and ulcers (19,20). The plant produces large edible fruits maturated between September and May according to the plant growing climate (21). Nowadays, pomegranate fruit is considered one of the main sources of antioxidant agents that have both health and medicinal beneficial properties (7,18). The pomegranate peel extract contains many bioactive compounds such as: Punicalagin, Ellagic acid, Punicalin, Quercetin, Gallic acid, Luteolin, Naringenin and Kaempferol (22,23). Furthermore, it has a known anti-oxidant, inflammatory and anti-carcinogenic properties (22).
Effect of Pomegranate Juice on Intestinal Recovery Following Methotrexate-Induced Intestinal Damage in a Rat Model
Published in Journal of the American College of Nutrition, 2018
Ron Shaoul, Dalia Moati, Betty Schwartz, Yulia Pollak, Igor Sukhotnik
Li et al. (8) investigated the effects of PMG extract and PMG juice on the growth of major groups of intestinal bacteria: Enterobacteriaceae, Bacteroides fragilis group, clostridia, bifidobacteria, and lactobacilli, and the utilization of pomegranate polyphenols by Bifidobacterium and Lactobacillus. PMG extract and PMG juice increased the mean counts of Bifidobacterium and Lactobacillus and significantly inhibited the growth of B. fragilis group, clostridia, and Enterobacteriaceae in a dose-response manner. Bifidobacterium and Lactobacillus utilized ellagic acid and glycosyl ellagic acid, but little or no punicalin was utilized. The effect of pomegranate on the gut bacteria considered to be beneficial (Bifidobacterium and Lactobacillus) suggests that pomegranate may potentially work as a prebiotic.
A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults
Published in Journal of Dietary Supplements, 2018
Joby Jacob, Sreeraj Gopi, Chandradhara Divya
The polyphenolic compounds such as anthocyanins, catechins, complex flavonoids, and hydrolysable tannins such as punicalin, pedunculagin, punicalagin, and gallic and ellagic acids are responsible for the biological activity of the pomegranate peel extract (Ismail, Sestili, & Akhtar, 2012). These molecules showed significantly high antioxidant activity and antimutagenic properties especially effective on lipid peroxidation and hydroxyl radical scavenging activity (Singh, Murthy, & Jayaprakasha, 2002; Negi, Jayaprakasha, & Jena, 2003; Murthy, Jayaprakasha, & Singh, 2002). The polyphenolic compounds and high amount of nutrients in pomegranate peel extract play a valuable role in providing the daily requirement of minerals; hence, pomegranate peel extract can be used in sports supplements (Mirdehghan & Rahemi, 2007).