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Role of Plant-Based Anti-HIV Agents in HIV-Associated Neurocognitive Disorders (Hand)
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Vishal K. Singh, Himani Chaurasia, Richa Mishra, Ritika Srivastava, Vivek K. Chaturvedi, Ramendra K. Singh
Lymphocytic propagation is persuaded through phyto haemagglutinin-induction and prolonged supervision of polyphenol-rich fruit juices, which revealed bioactivities against HIV-positive patients. The annins and subsequent phenolic derivatives have also shown virucidal impression within numerous viral organizations, such as, Lithospermic acid (Figure 2.3), which is extracted Salvia miltiorrhiza; and this acid has been effective against HIV when subjected to H9 cells [1]. Punicalagin, chebulagic acid, and punicalin have shown hydrolyzing properties and all three compounds can be obtained by Terminalia chebula showing their anti-HIV activities [44]. Repandusinic acid is extracted from Phyllanthus niruri and it demonstrates inhibitory activity against HIV-1 RTase [59].
Anti-HSV and Cytotoxicity Properties of Three Different Nanoparticles Derived from Indian Medicinal Plants
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
K. Vasanthi, G. Reena, G. Sathyanarayanan, Elanchezhiyan Manickan
Our study underlines the capacity of the nanoparticles which was derived from the plants extract against the HSV. Thus, our nanoparticles such as PgPSNP and PgJSNP revealed anti-HSV activity due to the presence of more active compounds punicalagin. Our also study supports the previous reporting, punicalagin (active compound) of the extract and juice of P. granatum were responsible for the antiviral activity. Thus, the fractionation of these bioactive compounds against the viral activity should be explored further [14, 15]. The active compounds in the remaining extracts might be less in quantities to inhibit the virus particles. Elucidation of those active compounds from those plants might be providing the new and effective antiviral agents. This study clearly indicated that P. granatum peels silver NP (PgPSNP) showed the maximum anti-HSV activity besides its minimal toxicity observed. Thus, PgPSNP is a novel anti-HSV drug which is worth pursuing.
Nanocarriers Systems and Their Application for the Delivery of Different Phytoconstituents
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Ebru Altuntaş, Gülgün Yener, Burcu Özkan
In an attempt to utilize the maximum therapeutic effects of bioactive compounds of pomegrenate and to provide the greatest protection against hydrolysis, punicalagin derived from Punica granatum peel was encapsulated by using nonionic surfactant and cholesterol with different ratios. F7 coded formulation containing 7:1:1 ratio of the surfactant:cholesterol:drug possessed maximum encapsulation efficiency and had the smallest vesicle size (Priya and Singh, 2012).
Antifungal and Anti-inflammatory Effect of Punicalagin on Murine Aspergillus fumigatus Keratitis
Published in Current Eye Research, 2022
Hao Lin, Qian Wang, Yawen Niu, Lingwen Gu, Liting Hu, Cui Li, Guiqiu Zhao
Punicalagin (PUN) is the most abundant ellagitannin in pomegranate and is widely used in traditional Chinese medicine.9 Previous studies have shown that PUN can play an active role in anti-inflammatory, antioxidant, anti-cancer, anti-fungal, anti-apoptosis, and anti-glycation response.10–14 Despite increasing interest in PUN’s capacities, there is no current literature reporting its influence on fungal keratitis. PUN has been shown to target macrophages9 and inhibit oxidative stress in LPS-induced macrophages,10 and previous studies suggest that it shows anti-fungal activity against the conidial and hyphal stages of dermatophytes, including Trichophyton mentagrophytes15 and three Candida species.16,17 Importantly, cytotoxicity assays show that PUN exhibits selectivity for fungal cells in preference to mammalian cells.15
Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species
Published in Nutritional Neuroscience, 2018
Maria Elisabetta Clementi, Giovambattista Pani, Beatrice Sampaolese, Giuseppe Tringali
In conclusion, this study shows for the first time the neuroprotective and anti-apoptotic effect of punicalagin on H2O2-induced cell death in PC12 cell. Furthermore, based on our observations, one can also imagine the punicalagin as a substance with a protective potential against neurodegenerative diseases. In fact, ROS are the trigger of the damage to the mitochondrial respiratory chain and of loss of mitochondrial membrane potential; all factors that mediate or amplify the neuronal dysfunction during the course of the neurodegeneration, and consequently implicated in the development of neurodegenerative diseases.13,26 Note, in addition, that the protective effect exerted by punicalagin has been observed with a easily achievable concentration with a portion of fresh pomegranate juice where punicalagin levels reach the dose of 2g/l.31
Punicalagin attenuates ventricular remodeling after acute myocardial infarction via regulating the NLRP3/caspase-1 pathway
Published in Pharmaceutical Biology, 2023
Jian-fei Peng, Xiao-ni Zhao, Meng Zhang, Jing-ya Li, Chun-chun Zhao, Shu-shu Wang, Jia-li Wang, Hui Shi, Peng Zhou, Liang Wang
Increased consumption of fruits and nuts is extremely beneficial to human health and can help to prevent several diseases. In terms of health nutrition and medicine, there is a growing interest in the study of food composition at present (Venusova et al. 2021). Punicalagin is the primary ellagitannin polyphenol found in the peel or seeds of the pomegranate, raspberries, strawberries, and walnuts (Hering et al. 2021), and it possesses anticancer, antiinflammatory, antioxidant, and antiviral properties (Xu et al. 2021). Punicalagin is effective in the treatment of a variety of diseases, including cervical cancer (Xie et al. 2022), lung cancer (Fang et al. 2021), acute leukemia (Subkorn et al. 2021), lupus nephritis (Seo et al. 2020), diabetes and its complications (Hua, Han, et al. 2022; Liu et al. 2022) bronchial asthma (Yu and Li 2022), rheumatoid arthritis (Ge et al. 2022), Alzheimer’s disease (Xu et al. 2022), and acute myocardial infarction (Ding et al. 2017). Punicalagin has good myocardial protection, which significantly enhanced cardiac function, decreased the size of infarcts, decreased CK-MB and LDH activity, and inhibited cardiomyocyte apoptosis (Ding et al. 2017). These studies indicated that punicalagin has good biological activity on AMI and is worthy of further study. Additionally, by suppressing the expression of NLRP3 and caspase-1, punicalagin was able to alleviate cell death caused by inflammation, as shown by the reduction of inflammatory cell death mediated by the production of IL-1β and IL-18 (An et al. 2020). However, it remains unclear whether the protective mechanism of punicalagin on VR after AMI is related to the regulation of NLRP3/caspase-1 signaling pathway.