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Osteoarthritis (Knee and Hip)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Methylsulfonylmethane (MSM): One preliminary study suggested that taking 6,000 mg of MSM improved pain and function without side effects in people with OA of the knee. Some preparations combine MSM with glucosamine to treat OA. One study suggests that this approach might help but more research is needed.10
Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, dimethyl-sulfoxide (DMSO), and glucosamine sulfate. Organic sulfur, as SAAs, can be used to increase synthesis of S-adenosylmethionine, glutathione, taurine, and N-acetylcysteine (14). MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as S-adenosylmethionine, dimethyl-sulfoxide, taurine, chondroitin sulfate, glucosamine, and reduced glutathione may also have clinical applications in the treatment of a number of ailments such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS (13). In addition, sulfur is needed for a number of chemical reactions involved in the metabolism of drugs, steroids, and xenobiotics (13). The other sulfur compounds of biological significance are thiocyanate (SCN) in saliva and other fluids, ergothioneine of the red blood cells, glutathione, present in all cells, and glucosamine and chondroitin sulfate, which serve a structural function in cartilage, bone, tendons, blood vessel walls, and so on (8).
Brittle Nails
Published in Nilton Di Chiacchio, Antonella Tosti, Therapies for Nail Disorders, 2020
Lacquers have been specifically developed to restructure nails affected by dystrophy and fragility. One of them is based on hydroxypropyl chitosan (HPCH), Equisetum arvense, and methylsulfonylmethane.4 Once applied to the nails, HPCH forms an invisible film that adheres to the nail structures and protects them from mechanical trauma. The chitosan polymer backbone bears hydrophilic residues that most likely explain the high affinity of HPCH with keratin. This lacquer is designed to decrease lamellar splitting. There is some data showing its effectiveness on psoriatic nails (Evidence B).5
Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates
Published in Expert Opinion on Therapeutic Patents, 2021
Harbinder Singh, Vikrant Rai, Sunil K. Nooti, Devendra K. Agrawal
To inhibit or activate the specific intracellular signaling cascade, modulation of TREM-2 is another approach. In 2017, Kang and colleagues [114] reported gold-containing agents for the treatment of liver cirrhosis or liver fibrosis via increasing the TREM-2 expression. Using Western blot analysis, they confirmed that especially auranofin (gold containing agent) (Figure 2) can induce transformation of macrophages to M2-type mouse macrophage cell line (RAW264.7) by increasing the expression of TREM-2 which can further effectively inhibit liver fibrosis. Recently in 2020, Mohamed et al. [115] treated Bisphenol-A and ℽ-radiation induced neuroinflammation with methylsulfonylmethane (MSM; organosulfur compound) in rats. They found that this treatment significantly improved the histopathological defects and neuroinflammation in animals by modulating TREM-2/DAP-12/Syk pathway. One major concern with this approach is the non-specificity due to the involvement of DAP10/12, Syk, and PI3K in many other signal transduction pathways. Thus, they are unlikely to become effective target in the context of TREM-2 specific therapy.
ESWT and nutraceutical supplementation (Tendisulfur Forte) vs ESWT-only in the treatment of lateral epicondylitis, Achilles tendinopathy, and rotator cuff tendinopathy: a comparative study
Published in Journal of Drug Assessment, 2019
Matteo Vitali, Nadim Naim Rodriguez, Pierluigi Pironti, Andreas Drossinos, Gaia Di Carlo, Anshuman Chawla, Fraschini Gianfranco
Methylsulfonylmethane (MSM) is a sulfur-containing compound. It is a natural component of vegetables, grains, fruits, and beverages. Through oral administration it is rapidly absorbed, well distributed, and completely excreted from the body. Fusini et al.1 state that it can be an efficacious analgesic and anti-inflammatory supplement. Its employment in the management of osteoarthritis showed a rapid reduction of pain and swelling while improving functional ability. In the literature, it is reported that MSM may have clinical applications for arthritis and other inflammatory disorders such as interstitial cystitis, allergic rhinitis, and acute exercise-induced inflammation. The mechanism of action includes the prevention of degradation of the NF-kB inhibitor, blocking of phosphorylation of the p65 subunit at Serine-536, the downregulation of the expression of inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) through suppression of NF-kB29.
Pharmacotherapy options for managing chemotherapy-induced peripheral neurotoxicity
Published in Expert Opinion on Pharmacotherapy, 2018
Guido Cavaletti, Paola Marmiroli
Dietary supplementation with α-lipoic acid, Boswellia Serrata, methylsulfonylmethane, and bromelain combined in a single capsule was tested in 25 subjects with CIPN emerging during or after chemotherapy with potentially neurotoxic agents. Analysis of VAS data showed reduction in pain perceived by patients, and this was supported by NCI-CTCAE sensory and motor scores and TNSc results. The authors reported no significant toxicity or interaction with chemotherapy and concluded that a ‘prospective randomized clinical trial in a selected patients’ population is warranted’ in order to confirm the effectiveness of the treatment. This mixed dietary supplement is based on a well-known antioxidant (α-lipoic acid), on the Ayurvedic medicine Boswellia Serrata used for hundreds of years for the treatment of arthritis in view of possible anti-inflammatory effects, the organosulfur also known as DMSO2 (methylsulfonylmethane) which might have several potential beneficial effects against toxic damage, and on bromelain, an extract containing proteolytic enzymes and a number of other substances in smaller quantities derived mostly from the stems of pineapples which has a history of folk medicine use as anti-inflammatory agent. Despite extensive investigation using well-established outcome measures, the nonhomogeneous population under investigation (treated with platinum drugs, taxanes, vinca alkaloids or eribulin, in some cases in combination), the study design (open label) and the low number of patients treated at different timepoints do not allow to safely interpret these positive results.