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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Citronellol is a colorless to pale yellow clear liquid; its odor type is floral and its odor is described as ‘floral, rosy, sweet, citrus with green fatty terpene nuances’ (www.thegoodscentscompany.com). Citronellol occurs naturally in many plant oils and certain fruits. The chemical is a component of citronella oil and is a main component responsible for the insect repellent properties of this essential oil. It is one of the most widely used fragrance materials, particularly for rose notes and for floral compositions in general. Its stability makes it particularly useful in fragrances for soaps, detergents, and other household products. Citronellol, in addition, is important as an intermediate in the synthesis of a number of other fragrance chemicals, including rose oxide, numerous citronellyl esters and hydroxydi-hydrocitronellol. The chemical is also used as a food flavoring and it is an important pesticide on food crops and ornamental plants (U.S. National Library of Medicine).
Phytotherapeutic Agents in Epilepsy
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Citronellol is an acyclic monoterpene alcohol, which is present in the essential oils of various aromatic plant species including citronella oil obtained from Cymbopogon nardus (Fam. Poaceae). This compound has been shown to demonstrate neuroprotective activity against PTZ-and PIC-induced convulsions and MES-induced seizures in mice. The results demonstrate that the anticonvulsant activity of citronellol could be, at least in part, explained by the diminution of the action potential amplitude.60
Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells
Published in Nutrition and Cancer, 2021
Jayaganesh Rajendran, Pugalendhi Pachaiappan, Rajakumar Thangarasu
Many phytochemicals have anticancer properties. At present, there is much interest in the intake of citrus fruits that appears to be related to reducing the risk of certain chronic diseases (10). Citronellol (CT) (3, 7-dimethyl-6-octen-1-ol) is a natural acyclic monoterpenoid (Figure 1), which is present in high quantities in citrus fruits and about 70 essential oils, predominantly in Bulgarian rose oil and geranium oil (11). This monoterpene has good flavoring property, hence used for food industries due to the presence of floral notes (12). CT has been reported to possess strong antioxidant, anti-diabetes, anticancer, cardioprotective and anti-inflammatory activities (13–15). Based on these reports, the cytotoxic action of CT against human mammary cancer cells and mechanisms of apoptosis was investigated. In MCF-7 cells MTT assay, Reactive oxygen species (ROS), Mitochondrial membrane potential assay (MMP), Acridine orange/ethidium bromide staining (AO/EtBr), Nuclear DNA damages cause changes in the structure of the genetic material of cells assessed by acridine orange staining (AO), Comet assay and protein expression of apoptotic markers whereas in MDA-MB-231 cells MTT assay and protein expression of apoptotic markers were studied.
Increased anxiety-related behavior in mice following β-citronellol inhalation
Published in Libyan Journal of Medicine, 2020
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
Citronellol, a monoterpene alcohol, is a naturally occurring monoterpene compound widely found in essential oils of various aromatic plant species, such as Cymbopogon citratus [12], C. winterianus [13], and Lippia alba [14]. β-citronellol (3,7-dimethyl-6-octen-1-ol; CAS number 106–22-9) is a volatile non-cyclic monoterpene found naturally in the essential oils of several plant species worldwide. β-citronellol is naturally abundant as a volatile component responsible for the pleasant aroma and flavor of fruits. β-citronellol has odor properties that render it useful in the perfume industry [15]. It is generally recognized as an edible compound. The acceptable daily intake of β-citronellol is 0.5 mg/kg body weight [3]. Some pharmacological actions of citronellol have been studied [16,17], including antibacterial, antifungal, antihypertensive, vasorelaxant and anticonvulsant effects [10,18,; 19].