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Functional Foods: Bioavailability, Structure, and Nutritional Properties
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Tawheed Amin, H. R. Naik, Syed Zameer Hussain, Bazila Naseer
Using the QSFR principle, delivery systems with physical stability could be designed. However, the long-term chemical stability of unsaturated (double bond containing) lipids (such as PUFAs, carotenoids, and CLA) is still a critical issue. The oxidation of dietary bioactive lipids results not only in the changes in sensory properties, but also may lead to the loss of its bioavailability [59]. There are various ways to combat such oxidation processes and one of the methods is the use of antioxidants [17]. The use of antioxidants in food industries is decreasing since most of the food industries are disinclined to use synthetic antioxidants due to their possible deleterious effects on human health and stern control over their level of incorporation. The aptness to control or prevent an oxidation of bioactive-lipid incorporated food products by synthetic antioxidants is often limited. In contrast, several natural antioxidants (rosemary extract, ascorbic acid, ascorbyl palmitate, and tocopherols) are currently being employed to protect the bioactive lipids from oxidation (stage 4 of Figure 1.3).
Cosmetic-Medical Treatments
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
M. Lourdes Mourelle, B. N. Díaz
Vitamin C or ascorbic acid: Along with vitamin E, this has been shown to be able to neutralize free radicals. Furthermore, it is essential for the synthesis of collagen fibers and plays a protective role for the skin against the erythema produced by the aggression of UV light [35]. For topical use, it is used in the forms of magnesium ascorbyl phosphate, magnesium ascorbyl palmitate, and magnesium ascorbyl tetraisopalmitate, which are more soluble and stable and more easily penetrate the skin.
Application of Bioresponsive Polymers in Drug Delivery
Published in Deepa H. Patel, Bioresponsive Polymers, 2020
Manisha Lalan, Deepti Jani, Pratiksha Trivedi, Deepa H. Patel
The management of local diseases of gastrointestinal tract like inflammatory bowel disease may become more efficient if a bioresponsive system releases drug at the site of inflammation. Zhang et al. developed an inflammation targeting hydrogel microfibers of ascorbyl palmitate which were loaded with model drug dexamethasone, it adhered to the inflamed mucosa and released drug at the site by enzymatic digestion. The novel system displayed success in both in-vitro and in-vivo conditions [29].
Ascorbic acid derivative-loaded modified aspasomes: formulation, in vitro, ex vivo and clinical evaluation for melasma treatment
Published in Journal of Liposome Research, 2020
Mona H. Aboul-Einien, Soha M. Kandil, Ebtsam M. Abdou, Heba M. Diab, Marwa S.E. Zaki
The aim of our work was to design a vesicular system for topical delivery of a hydrophilic ascorbic acid derivative, MAP, to promote its stability and enhance its skin permeation and retention. In addition to its antioxidant effect, Ascorbyl palmitate will be used to enhance the formation of nano-sized carrier vesicles (aspasomes). The effect of aspasomes composition on their physicochemical properties as well as drug release and skin permeation was investigated and the selected aspasomes formulation was formulated as semisolid dosage forms of different natures in order to designate a proper pharmaceutical system that can be used for subsequent clinical study. The selected novel MAP aspasomal topical formulation was evaluated for its clinical efficacy in melasma treatment in comparison with more conventional treatment in the form of chemical peeling using 15% trichloroacetic acid (TCA).
Formulation, optimisation and in-vitro, in-vivo evaluation of surfactant stabilised nanosuspension of Ginkgo biloba
Published in Journal of Microencapsulation, 2019
Saba Aslam, Nazish Jahan, Khalil-Ur-Rehman , Shaukat Ali
The Atomic Force Microscope allows the visualisation of a surface in three dimensions with sub-nanometer resolution. Figure 5 shows the AFM images of G. biloba nanosuspension. Topographic (10.00 × 10.00 µm) and 3 D images obtained by AFM showed approximate height of 15-30nm and sheet like shape of G. biloba nanoparticles. The particle size of optimised nanosuspension measured by AFM was quite different from Photon correlation spectroscopy (PCS) measurements. The difference in size was due to the fact that AFM measures physical diameter of the nanoparticles and PCS measures hydrodynamic diameter (Chicea 2010). Another reason for the smaller particle size measured by AFM was probably be due to solvation of nanoparticles. Before the measurement of particle size by AFM, lyophilised nanosuspension was suspended in distilled water and sonicated to obtain a homogenous suspension. During this process, nanoparticles may get dissolved (Wang et al.2011). Teeranachaideekul et al. (2008) observed cuboidal shape and 1 µm size of nanocrystals of ascorbyl palmitate produced by nanosuspension technology and stabilised by sodium lauryl sulphate. The morphology of nanosuspension of a poor water soluble drug SKLB610 was also studied with the help of AFM and spherical particles were observed (Huang et al.2013).
Pharmaceutical Formulation Methods for Improving Retinal Drug Delivery
Published in Seminars in Ophthalmology, 2019
Tomasz P. Stryjewski, James A. Stefater, Dean Eliott
To further improve the stability of the molecule in storage, another formulation method, lyophilization, is utilized. Lyophilization is the removal of water by sublimation (the direct passage of a state of matter from solid to gas phase). Lyophilization is performed by freezing the liquid drug product and then subjecting it to very high vacuum, which results in sublimation. However, the stresses of lyophilization can destabilize liposome spheres. For this reason, excipients, most commonly sugars, such as sucrose, lactose, or trehalose are added as “cryoprotectants.” These cryoprotectants form a stabilizing matrix around the liposomes that prevents their destruction during the harsh freezing cycle. In the case of Visudyne, lactose is used as the cryoprotectant. To further improve the product’s shelf stability, ascorbyl palmitate and butylated hydroxytoluene, free radical scavengers, are added as well. Therefore, although the “naked” active pharmaceutical ingredient verteporfin would be too unstable to be useful, through a series of pharmaceutical formulation steps, a drug product can be made that is practical for use in the clinic.