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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Previously, 9 patients (of who 6 in The Netherlands [6]) had become sensitized to mesulfen in an antimycotic ointment containing 8% mesulfen. Most had treated tinea pedis with the ointment and developed allergic contact dermatitis. Patch test concentrations were 5% (4,7), 8% (6) and 1% and 8% (5). These concentrations appear not to be irritant (3).
Therapy For Skin, Hair and Nail Fungal Infections
Published in Raimo E Suhonen, Rodney P R Dawber, David H Ellis, Fungal Infections of the Skin, Hair and Nails, 2020
Raimo E Suhonen, Rodney P R Dawber, David H Ellis
It is important to treat symptomatic tinea pedis and onychomycosis. Untreated tinea pedis may lead to severe reactive inflammation, with painful Assuring of the feet and toes. Occasionally, generalized ‘autosensitisation’ eruptions occur in response to persistent focal fungal skin disease. Onychomycosis may be asymptomatic and no more than an ‘aesthetic compromise’ in its early stages. However, progression of the disease frequently leads to complications, such as an ingrowing toenail and sometimes the painful nail-plate deformities of onychogryphosis and pincer or trumpet nail that may occur later in life. Studies of onychogryphosis in the elderly have shown that many such patients had untreated onychomycosis at a younger age. The initial capital cost of treating onychomycosis successfully is, therefore, fully justified.
Skin diseases of the elderly
Published in Robert A. Norman, Geriatric Dermatology, 2020
The fungal infections are dermatophytosis and candidiasis. The dermatophyte involvement is mainly tinea pedis, onychomycosis and dnea cruris. Tinea pedis is usually an erythematous scaling dermatitis with a moccasinlike presentation (Figure 10), with or without interdigital and dystrophic nail changes. Tinea cruris is a pruritic circinate erythematous scaling eruption of the groin. Tinea unguium is clinically a dull opaque yellowish-white discoloration of the nails, which can become britde, friable, hypertrophic and dystrophic. The diagnosis in all these clinical expressions is confirmed by demonstration of the septate branching hyphae under the microscope or a specific type of growth on Sabaroud’s culture medium. Candidal infection favors intertriginous moist areas i.e. flexural, submammary, anogenital and perioral (Figure 11). The eruption usually consists of ‘beef-red’ weeping areas with satellite pustules; it sometimes presents as inflammatory arcuate lesions, usually in the groin. The paronychial area can be involved especially in those who are diabetic and/or have their hands repeatedly wet. Again, the diagnosis is confirmed by demonstration of pseudohyphae and spores on microscopy or its characteristic growth on culture. The predisposing conditions are diabetes, antibiotics, nutritional factors and diminished salivary function.
Oxiconazole nitrate solid lipid nanoparticles: formulation, in-vitro characterization and clinical assessment of an analogous loaded carbopol gel
Published in Drug Development and Industrial Pharmacy, 2020
Rabab A. Mahmoud, Amal K. Hussein, Ghada A. Nasef, Heba F. Mansour
Both groups were treated for 4 weeks for tinea pedis and 2 weeks for other types of tinea fungal infections. Regarding group 1 that was treated with Tinox® cream, none of the patients assessed excellent evaluation (0%). One patient assessed good result (7.14%), four patients assessed moderate results (28.57%) while nine patients assessed mild results (64.2%). For group 2 that was treated with the prepared F3-loaded gel, nine patients assessed excellent results (64.2%), four patients assessed good results (28.57%), none of the patients assessed moderate results (0%) while one patient assessed mild results (7.14%). These results showed a significant variation between the two groups (p < 0.05) that is illustrated in Figures 6 and 7 for patients before and after treatment. These results were supported with the results of the KOH exam test that revealed partial disappearance of fungi spores after treatment with Tinox® cream while it showed entire disappearance of the spores after treatment with the prepared oxiconazole nitrate SLNs-loaded gel (Figure 8).
Consumer preferences of antifungal products for treatment and prevention of tinea pedis
Published in Journal of Dermatological Treatment, 2019
Tinea pedis, or athlete’s foot, is a dermatophyte infection of the plantar feet and interdigital spaces, affecting 70% of the world’s population at some time (1). Risk factors for infection include direct contact with the causative organism, most commonly Trichophyton rubrum. Trauma, as well as prolonged exposure to moisture contribute to risk, and re-infection is common (2), with recurrence attributed to both re-infection and failure to eradicate the original infection (1). Additionally, tinea pedis often precedes and is an important risk factor itself for onychomycosis. Onychomycosis, when chronic and severe may be difficult to treat, with recurrence rates (relapse or re-infection) ranging from 10–53% (3), emphasizing the importance of prevention [4]. In addition, treatment of co-existing tinea pedis has been shown to increase complete cure rates of onychomycosis (5).
Strategies to improve the diagnosis and clinical treatment of dermatophyte infections
Published in Expert Review of Anti-infective Therapy, 2023
To prevent tinea pedis in athletes, moisture-absorbing socks should be preferred, socks should be changed frequently, showers should be taken immediately after sports activity, athletes should never walk barefoot in the locker room, regular cleaning of the shower and locker room and pool floors should be performed, and athletes with recurrent infections should apply antifungal creams daily to their feet. Sharing socks, slippers, shoes and towels with other people should be avoided. Antimicrobial fabrics, instead of synthetic fabrics, can contribute to the control of dermatophytes [74]. Clothes should be washed at >60°C instead of 30°C [75].