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Herpes Simplex Virus Ocular Disease
Published in Marie Studahl, Paola Cinque, Tomas Bergström, Herpes Simplex Viruses, 2017
In the community-based series from Rochester, Minnesota, followed over 33 years (61,62), ocular HSV was defined as any form of herpes simplex, including lid, conjunctival, or cornea. Using this definition, 12% had bilateral ocular HSV and 28% were atopic. Most bilateral episodes represented lid and conjunctival disease at their first episode of ocular HSV. Simultaneous bilateral corneal involvement is uncommon.
Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus
Published in Expert Opinion on Biological Therapy, 2022
E Anitua, B de la Sen-Corcuera, G Orive, RM Sánchez-Ávila, P Heredia, F Muruzabal, J Merayo-Lloves
The pioneering use of mPRGF for surgical purposes was reported in 15 patients who suffered from corneal or conjunctival diseases such as persistent epithelial defects, pterygium, or keratoplasty [103]. In this study, a mPRGF was sutured either alone or combined with amniotic membrane. All patients showed some improvement after mPRGF treatment, from which 87% achieved complete closure of the defect as well as significant improvement in BCVA, intraocular pressure (IOP) and inflammation (redness and pain) values. Interestingly, patients undergoing combined mPRGF/MA placement showed longer healing times compared to mPRGF alone (4 vs 2.4 months). This preliminary study suggests that the use of mPRGF can be considered safe and effective, being a potential alternative to the AM use [64].
Plasma cell granuloma of the conjunctiva in a young female
Published in Orbit, 2021
Md. Shahid Alam, Vathsalya Vijay, Atanu Barh, Krishnakumar Subramanian
Plasma cell granuloma is a rare non-neoplastic inflammatory condition of unknown etiology. Histologically it is characterised by proliferation of polyclonal plasma cells, lymphocytes, neutrophils, eosinophils, and histiocytes in a fibrotic background.1 The exact etiology and natural history of these lesions remain unclear. Some authors include it within the spectrum of IgG4-related disease.2 Though any part of the body can be involved, the most frequently reported are lungs and gastrointestinal tract3 There is no consensus on the exact management of this otherwise enigmatic disorder; surgical excision, radiotherapy, steroids, and immunosuppressants have been used with varying results.4 Conjunctival disease per se is very rare and usually associated with involvement of other organs.5 The current case report describes a bilateral conjunctival plasma cell granuloma in a young patient without any systemic involvement. The present article adheres to the tenets of the declaration of Helsinki. The patient’s parents gave consent for publication of photograph and other details for research purpose.
Improving glaucoma management for the Boston keratoprosthesis type 1: tubes versus lasers
Published in Expert Review of Ophthalmology, 2020
Dominique Geoffrion, Mona Harissi-Dagher
Concurrent GDD placement with KPro implantation, both performed at the same time, appears to be an interesting option to explore. Kamyar et al. reported that 3 of the 11 eyes (27%) with concurrent GDD implantation, with insertion of the tube into the anterior chamber, suffered occluded tubes postoperatively [10]. These eyes necessitated subsequent pars plana vitrectomy and repositioning of the tube into the vitreous cavity. The authors recommended that glaucoma surgery be performed prior to or concurrently to KPro surgery to improve postoperative IOP elevation control [10]. In other studies, GDD placement combined with KPro surgery performed at the same time was not associated with increased KPro failure rates or postoperative complications in comparison to KPro alone [49,64]. AGV installed at the same time as KPro implantation did not lead to more complications and no glaucoma valve became exposed during the length of 3.6 years of follow-up in the study by Lenis et al. [49]. Patel et al. reported that placement of GDD at the time of KPro implantation leads to significantly favorable visual outcomes compared to sequential surgeries [60]. However, a quarter of patients suffered GDD erosion similarly whether a tube shunt was placed prior to or concomitantly with KPro surgery [61]. Because cicatricial conjunctival disease with fornix shortening is challenging and limits the use of GDD in KPro eyes, Cortina et al. reported the success of fornix reconstruction to allow for subsequent combined KPro and GDD surgeries in patients who were otherwise poor candidates [65].