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Animal Models of Ligament Repair
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Jason J. McDougall, Robert C. Bray
Synthetic ligaments have been used to investigate the effect of supplementary support during cruciate ligament repair. One type of artificial ligament is the augmentation device which was designed to allow joint loads to be shared during autologous ligament healing or graft establishment.55,56 The protective effect the prosthesis imparts is only supposed to be temporary, with it carrying the greatest amount of load immediately after implantation and then gradually transferring load onto the repaired tissue so that it may eventually become a more functionally competent structure.
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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Knee Injury [Anglo-Saxon: cneow, knee] Surgery for displaced semilunar cartilage of the knee was first performed on a 30-year-old miner by Thomas Annandale (1838–1909) from Newcastle-upon-Tyne in 1884. The replacement of lateral ligaments with artificial ligaments in cases of knee injury was first performed by Frederick Jay Cotton (1869–1938), a surgeon at Newport, Rhode Island in 1934.
Biomechanical effect of posterior ligament repair in lamina repair surgery
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2023
Kaixiang Jin, Yuanjun Zhu, Nan Li, Yinghui Li, Yan Yao, Zhongjun Mo, Yubo Fan
As previous studies point out, the posterior ligaments are believed playing important roles in tethering or tension constraint during anterior flexion or enhancement of spinal stability (Menku et al. 2010). Thereby, new methods to conserve ISL during lamina repair surgery were proposed (Joson and McCormick 1987), and ISL reconstruction by using artificial ligament was also suggested (Hirofuji et al. 1990). However, are there apparent benefits in term of biomechanical performances of lamina repair surgery combined with posterior ligament repair than that without posterior ligament repair? In the present study, a finite element cervical spine model (C2-C7) was built and used to simulate the lamina repair surgery with and without posterior ligaments repair at C3-C6 segments, to investigate the biomechanical effects of ligament repair on the cervical spinal stability in lamina repair surgery.
Promoting vascularization for tissue engineering constructs: current strategies focusing on HIF-regulating scaffolds
Published in Expert Opinion on Biological Therapy, 2019
Tilman U. Esser, Kaveh Roshanbinfar, Felix B. Engel
To improve applicability to soft tissues, microfibers made of bioactive glass have been produced by applying a high-pressure gas jet onto molten glass and subsequent quenching [109]. Ionic dissolution of Cu2+-doped borate bioactive glass microfibers enhanced tube formation and VEGF concentration in HUVEC in vitro by 300% and 400%, respectively, compared to such without Cu2+ ions. Furthermore, fibroblasts treated similarly, expressed significantly higher levels of VEGF, FGF, and PDGF. Wound healing studies in rat animal models with Cu2+-doped borate bioactive glass microfibers resulted in improved wound healing with enhanced vessel area coverage (from 20% to 35%) and number of newly formed vessels (from 70 to 130) after 14 days compared to microfibers without Cu2+ ions [109]. In another approach, Cu2+-containing borate bioactive glass was deposited onto eggshell membranes to allow for application in a wound closure model. Cu2+-bioactive glass/eggshell membranes increased angiogenesis and, although not significantly, accelerated wound closure, compared to membranes without Cu2+ [110]. A similar approach was used to coat polyethylene terephthalate artificial ligaments with Cu2+-bioactive glass [111]. Cu2+-bioactive glass/polyethylene terephthalate grafts showed also enhanced angiogenesis as well as improved graft integration in vivo.
Biomechanical analysis of a ligament fixation system for CCL reconstruction in a canine cadaver model
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2019
B. Goin, P. Rafael, Q. Blanc, T. Cachon, P. Buttin, C. Carozzo, P. Chabrand, E. Viguier
Quasi-static tests are shown in Figure 1. No rupture of the set-up occurred. An initial slipping load Is = 309 N ± 151 N (mean ± sd) of the prosthesis was observed at 3.78 mm ± 2.22 mm. Then, the maximum strength Ms = 800 N ± 132 N was reached at 24.4 mm ± 8.73 mm. No significant difference was observed between Ms native and artificial ligaments (ttest, P = 0.87).