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Pharmacokinetic-Pharmacodynamic Correlations of Antihistamines
Published in Hartmut Derendorf, Günther Hochhaus, Handbook of Pharmacokinetic/Pharmacodynamic Correlation, 2019
Eric Snoeck, Achiel Van Peer, Jos Heykants
Although the histamine-induced skin test is most commonly used for the evaluation of the antihistaminic effect, also morphine-, codeine-, methacholine-, and suxamethonium-induced skin reaction measurements have been reported to evaluate effects on other types of skin reactions.30–33 In allergic patients, skin prick-test responses to certain antigens may also be used for the evaluation of the antiallergic activity.
Changing “Unchangeable” Bodily Processes by (Hypnotic) Suggestions: A New Look at Hypnosis, Cognitions, Imagining, and the Mind-Body Problem
Published in Anees A. Sheikh, Imagination and Healing, 2019
The subject works at a hospital as a nurses’ aide. A few days prior to receiving a routine Mantoux test (a skin prick test utilizing old tuberculin for determining the possible presence of tuberculosis), she was told by a co-worker, “It’s really awful. They stick you with a needle a bunch of times, it really hurts terribly. …” Our subject said that, while her co-worker was describing the skin prick test, she clearly could feel the pain of the (imagined) needle puncturing her arm in a specific spot. She further related that she was later surprised to discover a skin reaction, a wheal, on the exact spot on her arm where she had imagined the skin pricks. The next day, she showed me the wheal, and it remained on her arm for almost a week.
Acute CSF rhinorrhoea
Published in S. Musheer Hussain, Paul White, Kim W Ah-See, Patrick Spielmann, Mary-Louise Montague, ENT Head & Neck Emergencies, 2018
When assessing spontaneous leaks, intrathecal injection of fluorescein may be useful to locate or confirm the defect (Figure 3.7); however, this is not generally used in the acute situation. If it is used, the patient should be consented and made aware that intrathecal injection is not a licensed use of fluorescein. As part of the work-up, a skin prick test using a drop of topical fluorescein (as used in ophthalmology) should be performed in case the patient has an allergy to the compound, and the patient should also be given IV chlorphenamine immediately prior to injection. It is important that the intrathecal injection is given prior to induction of anaesthesia in case a reaction occurs – if there is none, the patient may be anaesthetised and left head down for 30–60 minutes.
Updates in the diagnosis and practical management of allergic rhinitis
Published in Expert Review of Clinical Pharmacology, 2023
Chiara Trincianti, Maria Angela Tosca, Giorgio Ciprandi
The second step is the documentation of sensitization, such as the production of allergen-specific IgE. Allergen-specific IgE can be measured by a skin prick test and/or serum assay [17]. A skin prick test is cheap and quick to obtain helpful information about possible sensitization. Skin prick test is usually safe, but the reliability depends on avoiding interfering conditions, mainly concerning concomitant treatments with medications that interfere with results (typically antihistamines that should be withdrawn before). However, a serum assay is more precise and detailed than a skin prick test, mainly concerning the molecular diagnosis [18,19]. In particular, molecular diagnostics allows us to define the real allergen source and may be predictive for allergen immunotherapy [20]. Moreover, molecular diagnostics has relevant value if a comorbid food allergy exists as it may identify the risk level for severe allergy [21].
Relationship between sputum periostin level and inflammatory asthma phenotypes in Egyptian patients
Published in Journal of Asthma, 2021
Maged Mohamed Refaat, Eman El Sayed, Wael Abd El-Fattah, Amr Helmy Elbanna, Hoda Mohamed El Sayed
Skin prick test (SPT) to common allergens (prepared at the allergen extract unit, Faculty of Medicine, Ain Shams University) such as house dust mite, mixed molts, hay dust, horse hair, mixed pollens, goat hair, cat hair, cotton dust, tobacco, pigeon, dog hair, cockroach, straw, feather, wool, and latex. All antihistamines were omitted for 24–72 h before testing. After sterilization of the forearm with propyl alcohol swab, a drop of each allergen extract was put on marks 1 cm apart. Additionally, a drop of histamine phosphate and a drop of saline 0.9% were used as positive control and negative control, respectively (17). The immediate response was evaluated after 20 min. A skin test panel was considered valid if the difference in mean wheal diameters between the positive and negative controls was at least 1 mm. A wheal diameter ≥ 3 mm more than the negative control was considered positive (18).
Factors associated with serum IgM concentrations: a general adult population study
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2021
Iago Carballo, Manuela Alonso-Sampedro, Rosa-María Escribano, Carmen Fernandez-Merino, Bernardo Sopeña, Carmen Vidal, Francisco Gude, Arturo Gonzalez-Quintela
All participants underwent a panel of skin prick tests for relevant aeroallergens in the geographic area. The panel included house dust mites (Dermatophagoides pteronyssinus and Lepidoglyphus destructor), pollens (Phleum pratense, Plantago lanceolata, Betula alba, and Parietaria judaica), plant panallergens (profilin and peach lipid transfer protein), molds (Alternaria alternata and Aspergillus spp.), and animal dander (dog and cat) (ALK-Abelló, Spain). The control tests included 10 mg/mL histamine and saline solution, and standard procedures were followed [23]. Wheals with a mean diameter >3 mm after 15 min were deemed positive. The presence of at least 1 positive skin prick test was considered indicative of allergic sensitization or atopy [24], as previously described [21].