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The Prelude of Green Syntheses of Drugs and Natural Products
Published in Ahindra Nag, Greener Synthesis of Organic Compounds, Drugs and Natural Products, 2022
Leonardo Xochicale-Santana, C. C. Vidyasagar, Blanca M. Muñoz-Flores, Víctor M. Jiménez Pérez
Mechanosynthesis is a technique based on solid-state reactions, using grinding as a process. An advantage of this technique is to avoid the excessive use of solvents to carry out a successful chemical reaction. The development of this technique as a synthetic method has been excellently supported by obtaining results over the last few years in a wide variety of applications,6 as a method for obtaining leading drug structures. For example, Colacino and co-workers prepared disubstituted hydantoins using an eco-friendly methodology,7 applying the mechanosynthesis technique as an easy-handling tool. Hydantoins are a group found in a wide variety of drugs, hydantoin derivatives are used as anticonvulsants,8 muscle relaxants, antidiabetics,9 antiandrogenic, or antifungal activities.10 The application of this tool entails obtaining the disubstituted hydantoins in excellent yields from amino ester hydrochloride (1), in addition to avoiding the use of toxic substances to prepare said structures.11 This methodology was applied to the “green synthesis” of the antiepileptic drug Phenytoin (Scheme 15.1).
Preparation Methods of Hydrogen Storage Materials and Nanomaterials
Published in Mieczyslaw Jurczyk, Handbook of Nanomaterials for Hydrogen Storage, 2017
Marek Nowak, Mieczyslaw Jurczyk
Reactive mechanical milling can be realized by reacting two chemical compounds A and B in a solid-state synthesis that yields a distinct chemical compound C. This is termed mechanical synthesis or mechanosynthesis. Reactive milling can also be conducted by milling metal powders in ball mills filled with a reactive gas.
Study of the structural and magnetic properties at high temperature of Ni-Co-Mn-Al Heusler alloy prepared by an unconventional route
Published in Philosophical Magazine, 2023
Recently, various techniques have been developed for the elaboration of magnetically soft nanomaterials. Mechanical alloying (MA) or mechanosynthesis is one of common elaboration techniques. This technique is represented in a high-energy ball milling process that relies on the mechanical deformation process by repeating the welding and cold fracture phenomena. As a result, out-of-equilibrium powder mixtures are formed with a nanometric grain size [27].