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Nanoparticles for Cardiovascular Medicine: Trends in Myocardial Infarction Therapy
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Alternative material strategies for nanoparticle generation, although not recently employed for MI therapy, may serve as suitable approaches to diversify MI therapy. DNA nanostructures can be precisely assembled to exhibit chemical and morphological characteristics and can offer considerable prospects to delineate information concerning the nanoparticle–biological interface (Lee et al. 2016a). Structural DNA nanotechnology is considered a promising stratagem for drug delivery (Ke et al. 2018). Artificially constructed nucleic acid nanodevices have been engineered to release payloads upon sensing certain tissue microenvironments (Fan et al. 2020a). Moreover, several studies proposed the use of various DNA nanostructure strategies to encapsulate biomolecular drugs for their specific release within cardiac tissues (Zhang et al. 2019).
Interactions of Multiple Dynein Motors Studied Using DNA Scaffolding
Published in Keiko Hirose, Handbook of Dynein, 2019
DNA nanotechnology divorces DNA from its usual genetic context and instead reimagines assemblies of DNA molecules as a programmable substrate for diverse nanotechnological applications [33]. The functional application for these DNA devices depends heavily on a particular attribute of DNA’s chemistry: the affinity of two complementary strands of DNA depends on the length and sequence of those strands. Leveraging this unique chemistry of DNA, and employing user-defined sequences of bases, both static and dynamic interactions between many separate strands of DNA can be achieved [33]. “DNA origami” [34, 35], as a specific technique within the wider field of structural DNA nanotechnology [18], is of particular use for cell biologists seeking to create specified macromolecular assemblies with predictable, and controllable, architectures [19, 36]. DNA origami, as a method, enables static and stable volumetric three-dimensional nanoscale structures to be self-assembled with programmed binding sites that are uniquely addressable. Ultimately, this allows diverse structures to be designed with user-determined shape and size.
Studying Biologically Templated Materials with Atomic Force Microscopy
Published in Sivashankar Krishnamoorthy, Krzysztof Iniewski, Nanomaterials, 2017
Andrew J. Lee, Christoph Walti
Great interest in this field has led to a large number of publications demonstrating 2D and 3D structures of increasing complexity. In addition, the technique was greatly expanded with the introduction of DNA origami by Paul Rothemund in 2006.53 This new methodology simplified the design process by relieving some of the limitations imposed by the small number of nucleotide interactions available. Here, a large single-stranded DNA template, typically a viral genome, is folded into the desired shape through duplex formation with hundreds of short DNA strands, known as staple strands. This form of structural DNA nanotechnology has greater stability and typically more favorable assembly kinetics. It can easily be extended to enable the assembly of heterogeneous arrangements of multiple DNA origami tiles through additional base-pair interactions in order to form larger structures. Such structures have great potential as scaffolds for DNA-templated materials.
Beyond the smiley face: applications of structural DNA nanotechnology
Published in Nano Reviews & Experiments, 2018
Aakriti Alisha Arora, Chamaree de Silva
A multitude of new DNA applications have been introduced since the discovery of the double helix structure in the mid-twentieth century (Figure 1). One application that is proving to be promising in a variety of fields is DNA nanotechnology. DNA nanotechnology refers to the design, study, and application of synthetically created DNA nanostructures. The physical and chemical properties of DNA, rather than its genetic properties, are particularly malleable for various applications in the field of DNA nanotechnology [1]. In other words, the field of DNA nanotechnology aims to design synthetic DNA constructs that exhibit structures and functions that are not found for DNA in nature. Ultimately, natural properties of DNA are harnessed as tools that can be manipulated and applied in a variety of settings related to the field of biotechnology.