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Manufacture of Pressure-Sensitive Products
Published in István Benedek, Mikhail M. Feldstein, Technology of Pressure-Sensitive Adhesives and Products, 2008
As discussed in Ref. [54], cutting and die-cutting depend on the solid-state components of the laminate (face stock and release liner). Their quality and combination are very important. Good die-cutting is provided by a uniform caliper densified paper liner. Die-cuttability tests have been carried out using PE, PE/PP, PET and PET/SiO2 and paper (80 g/m2) as liner and face stock material to test cutting knife wear [57]. The influence of the face stock material and release on die-cutting was studied with rotary die-cutting by Hartmann et al. [58]. The investigations demonstrated the importance of an appropriate release liner for each face stock material, depending on its cutting and tear mechanism. The versatility of the release liner as a cutting basis depends on its chemical nature, mechanical properties, and dimensional tolerance.
Transdermal Drug Delivery
Published in Emmanuel Opara, Controlled Drug Delivery Systems, 2020
Brahmeshwar Mishra, Gunjan Vasant Bonde
The release liner is the component of TDDS, which is in intimate contact with the adhesive layer during storage and transportation that is peeled off and discarded before the application. The liner is made up of a chemically inert material. Polyester foils and other metalized laminates can also be utilized for the purpose. The base of release liner is fabricated from nonocclusive (e.g., paper fabric) or occlusive (e.g., polyvinylchloride, polyethylene) material, whereas a release coating layer is prepared from silicon or Teflon (Alexander et al. 2012, Kandavilli, Nair, and Panchagnula 2002).
Pressure-Sensitive Adhesives
Published in A. Pizzi, K. L. Mittal, Handbook of Adhesive Technology, 2017
The pressure-sensitive laminate manufactured to protect the adhesive-coated surface of a tape or a label is a temporary construction. In such products, the release liner may protect the adhesive or other components incorporated in the adhesive layer. Another role of the separate release liner is that of a continuum passing through the coating, converting, and labeling machines carrying the discontinuous label. Decals or labels applied manually do not need this function.
Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartments
Published in International Journal of Smart and Nano Materials, 2023
V. Chiaula, J. Jeppe Madsen, F.B. Madsen, P. Mazurek, A. C. Nielsen, A. L. Skov
The mixtures (silicone and glycerol, or silicone and glycerol containing CD:Oct) were stirred for a total of 2 min: 1 min by hand-mixing with a spatula, followed by 1 min at 3500 rpm with a dual asymmetric centrifuge SpeedMixer DAC 150 FVZ-K (DE). No additional degassing of the formulations was necessary. The obtained glycerol-in-silicone emulsions were coated onto a PET backing film with a commercial knife (gap size of 0.4 mm) and an RK K Control Coater with a speed of 23 mm/s to obtain adhesives approximately 0.3 mm thick. The samples were subsequently cured at 80 ± 1°C for 1 h. All samples were covered with an FEP release liner after coating; this liner was removed before any measurement took place. Adhesive thicknesses were measured prior testing between two liners with pre-determined thicknesses using a Mitutoyo digital thickness gauge (DE).
Mathematical modelling of drug-diffusion from multi-layered capsules/tablets and other drug delivery devices
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2022
Transdermal drug delivery provides an adequate suitable route for oral drug delivery having a large number of benefits over other drug delivery routes. A typical transdermal patch is composed of an adhesive matrix which contains the drug in-between a backing layer and release liner. Examples include nicotine patches which deliver a constant dose of nicotine across the skin that helps to relieve the symptoms associated with tobacco withdrawal, scopolamine for motion sickness, testosterone and oestrogen for replacement therapy, nitroglycerin for angina pectoris, fentanyl as analgesia and clonidine for hypertension. Therefore in this case, the domain consists of a two-layered transdermal patch and various layers of the skin (target tissue), mentioned in Table 3. Thus in this framework, there is an aggregate of nine layers (two layers of the transdermal patch and seven layers of the dermal region). Hence, taking n = 9, Eqs. (21) and (22) are simulated using the physiological values of various parameters given in Tables 3 and 4 with the help of Wolfram MATHEMATICA software, to obtain the concentration and diffusion profiles in the corresponding layers. The model simulations are presented graphically in Figures 11 and 12.