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Microwave-Assisted Synthesis: Revolution in Synthetic Chemistry
Published in Satish A. Dake, Ravindra S. Shinde, Suresh C. Ameta, A. K. Haghi, Green Chemistry and Sustainable Technology, 2020
Spiro[3H-indole-3,20-[4H] pyrido[3,2-e]-1,3-thiazine]-2,40(1H)diones does not form under conventional conditions, can be prepared by treatment of ‘in situ’ generated 3-indolylimine derivatives with 2-mercaptonicotinic acid under MW irradiation in absence of any solvent or solid support. The facile one-pot reaction is generalized for a variety of ketones and amines to give pure pyrido [3,2-e] thiazine derivatives, which do not require further purification processes was developed by A. Dandia et al. [14] Scheme 10.8.
Synthesis of novel quaternary ammonium salts from 1, 2-benzothiazine derivatives
Published in Journal of Sulfur Chemistry, 2021
Salman Gul, Maria Saleem, Munawar Ali Munawar, Hafiz Adnan Ahmad, Ejaz Ahmed, Robina Begum, Zahoor H. Farooqi
Thiazines are six-membered ring heterocyclic systems containing sulfur (S) and nitrogen (N) atoms in the same ring. When they are fused with the benzene ring, they produce bicyclic system containing N and S atoms in the same ring, which is known as benzothiazine. Different derivatives of benzothiazine have excellent microbial activities. Benzothiazines are known as antipsychotic drugs since last few decades [7]. Potent anticarcinogenic, antiinflammatory, fungicidal, herbicidal, antimicrobial and analgesic actions of benzothiazine derivatives has been widely reported in the literature [8–10]. Benzothiazine derivatives are also useful in antioxidant [11] and anticancer areas [12]. They are also used as precursors for the preparation of different organic compounds having anticorrosion [13] and antidiabetic activities [14].
Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study
Published in Journal of Sulfur Chemistry, 2019
Toktam Afrough, Mehdi Bakavoli, Hossein Eshghi, Javad Tajabadi, Joel Mague
The first attempt to synthesize 1,3-thiazines was made by Meyers in 1960 by the treatment of mercaptoalcohols with nitriles in concentrated sulfuric acid [7]. Several reviews summarizing subsequently published methods for the synthesis of 1,3-thiazine scaffolds and fused heterocyclic compounds possessing 1,3-thiazine core [8,9]. In addition, pyrimidothiazines are a class of heterocyclic compounds that have been described as corrosion inhibitors for carbon steel in 1.0 M HCl [10–12], filament temperature sensitive protein Z (FtsZ) inhibitors [13], 15-LO inhibitory activities [14] and anti-inflammatory and antipyretic agents [15]. The main synthetic methods for the formation of various bicyclic pyrimidothiazines involve reaction of pyrimidine-2-thiones with urea, 1,2-epoxy-3-chloropropane, 3-bromopropanoic acid derivatives, acetylene dicarboxylates or DMF-DMA and carbon disulfide [16].