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Antioxidants
Published in Leslie R. Rudnick, Lubricant Additives, 2017
Robert G. Rowland, Jun Dong, Cyril A. Migdal
Thiadiazole derivatives, particularly the monomers and dimers, represent another class of sulfur- and nitrogen-bearing multifunctional additives with antioxidant activity. For example, a monomeric 2-alkylesterthio-5-mercapto-1,3,4-thiadiazole has been reported to increase the oxidative stability of engine oils under thin-film oxidation conditions as measured by the Thin-Film Oxygen Uptake Test (TFOUT, ASTM D7098) [32]. Lithium 12-hydroxystearate grease containing the dimer 2,5-dithiobis(1,3,4-thiadiazole-2-thiol) exhibited superior oxidative stability in the ASTM D942 pressure vessel oxidation method [33]. When used in conjunction with alkylated diphenylamine and organomolybdenum compound, the thiadiazole derivative improved the Thermo-Oxidation Engine Oil Simulation Test (TEOST®, ASTM D7097) deposits relative to a control engine oil containing sulfurized isobutylene instead [34]. In addition to providing antioxidant benefit, the thiadiazole derivatives have been widely used as ashless antiwear and extreme pressure additives. Some of them can also provide corrosion inhibition and metal deactivation properties to nonferrous metals such as copper.
Microwave Synthetic Technology
Published in Banik Bimal Krishna, Bandyopadhyay Debasish, Advances in Microwave Chemistry, 2018
Biswa Mohan Sahoo, Bimal Krishna Banik, Jnyanaranjan Pa
Thiadiazole compounds are designed as anti-diabetic agents using docking studies. The designed thiadiazole derivatives are synthesized by cyclisation between aromatic acid and thiosemicarbazide using concentrated H2SO4 and condensing the product in the presence of aldehyde by microwave irradiation [107].
Synthesis and characterization of the Co(II) and Ni(II) complexes of 1,3,4-thiadiazole-derived ketones and secondary alcohols: thermal and magnetic properties
Published in Journal of Coordination Chemistry, 2021
Melih Erdogan, Kubra Kiymaz, Hakan Tahtaci, Saban Uysal
Cyclic structures that contain atoms other than carbon and hydrogen such as oxygen, nitrogen, or sulfur are heterocyclic compounds [2]. Studies have shown that heterocyclic compounds and their derivatives exhibit a wide range of biological activities [3]. Therefore, such compounds have an important role in the discovery of drugs. Thiadiazole and its heterocyclic derivatives are among the heterocyclic compounds used in existing commercial drugs and in many different fields. Thiadiazole is a five-membered heterocyclic aromatic compound containing two nitrogens and a sulfur, C2H2N2S. Thiadiazole and its derivatives have become the focus of attention in drug, agriculture, and material chemistry due to their high activity [4–12]. There are four different isomers of thiadiazoles, 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole, and 1,3,4-thiadiazole [12]. Specifically, 1,3,4-thiadiazole and its derivatives are highly reactive and have numerous biological activities; therefore, studies on the synthesis, characterization, and biological activities of this compound and its derivatives are continuing [13–16].
Solid-phase synthesis of sulfur containing heterocycles
Published in Journal of Sulfur Chemistry, 2018
Kulburn and coworkers [65] used resin-bound thiosemicarbazides in two synthetic protocols for the preparation of substituted 1,3,4-thiadiazoles (Scheme 33). In first strategy, the 1,3,4-thiadiazoles were synthesized by treating thiosemicarbazides with aldehyde followed by cyclization with ferric chloride. In other protocol, the 1,3,4-thiadiazoles were formed when thiosemicarbazides were reacted with DPT in CH2Cl2 [19].
Advances in the synthesis and chemical transformations of 5-acetyl-1,3,4-thiadiazolines
Published in Journal of Sulfur Chemistry, 2021
Samir Bondock, Tallah Albarqi, Mohamed Abboud
Thiadiazole is a five membered heterocyclic compound containing one sulfur atom and two nitrogen atoms and it can be achieved via direct C–H sulfurization with elemental sulfur [1,2]. Thiadiazole can exist in four possible isomeric structure, in particular, 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole and 1,3,4-thiadiazole (Figure 1) [3].