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Pleural disease induced by drugs
Published in Philippe Camus, Edward C Rosenow, Drug-induced and Iatrogenic Respiratory Disease, 2010
Mesalamine, a molecule composed of sulfasalazine linked to a sulfapyridine moiety, is used in the treatment of inflammatory bowel disease. Adverse effects, which are related to the sulfapyridine component, include gastrointestinal intolerance, urticaria, drug-induced lupus, hepatitis, blood dyscrasia and interstitial nephritis. There have been two reports of pleuro-pericarditis and an eosinophilic pleural effusion with parenchymal infiltrates associated with mesalamine therapy for ulcerative proctitis and presumed inflammatory bowel disease. After 2 weeks of mesalamine, a patient presented with fever, fatigue, chest pain, acute pericarditis and a small left pleural effusion without parenchymal infiltrates. The patient was re-challenged with mesalamine after the chest pain had resolved and recurrent symptoms developed which resolved after 1 week of systemic corticosteroids. Antinuclear antibodies and serological studies for viral pathogens were negative, suggesting that the clinical presentation was a mesalamine-induced hypersensitivity reaction. The second patient developed an eosinophilic pleural effusion with peripheral eosinophilia and parenchymal infiltrates following mesalamine therapy for presumed inflammatory bowel disease.35 Drug cessation and systemic corticosteroids resulted in complete remission of the radiographic abnormalities over a few months.
Sorption of pharmaceuticals and personal care products (PPCPs) from water and wastewater by carbonaceous materials: A review
Published in Critical Reviews in Environmental Science and Technology, 2022
Ming Zhang, Jialing Shen, Yuchi Zhong, Tao Ding, Pavani Dulanja Dissanayake, Yi Yang, Yiu Fai Tsang, Yong Sik Ok
PPCPs such as TCS, sulfapyridine (SPY), SMT, and SMX can be protonated or deprotonated at different pH values, showing different charge properties, and thus influencing electrostatic interactions. For instance, the different ionization species of sorbate show significant differences in the sorption capability. Zhang, Pan, et al. (2010) studied the contribution of ionization to the sorption of SMX by CNTs, finding that neutral SMX contributed more than 80% to total sorption. Liu et al. (2016) found that the sorption affinity of rGO for different species of two SAs (sulfapyridine and sulfathiazole) follows the sequence: SA0>SA+>SA under three selected pH values, indicating that the neutral form of SA contributed most predominantly to the sorption. Protonation may also alter the hydrophobicity of PPCPs, and subsequently influence sorption capacities. For example, the protonated TCS are more hydrophobic than their deprotonated anions, leading to the observed higher sorption capacity of protonated TCS by biosolids-derived biochar (Tong et al., 2016). In addition, ionized PPCPs and their dissociation state also affect the strength of hydrophobic and π-π EDA interactions. It has been reported that the ionization of amine and hydroxyl groups at high pH values makes them stronger electron-donor groups, which enhances the π-π EDA interaction (Chen, Duan, et al., 2008).
Determination of antibiotics during treatment of hospital wastewater using automated solid-phase extraction followed by UHPLC-MS: occurrence, removal and environmental risks
Published in Environmental Technology, 2023
Zamazwi Lukhanyiso Mthiyane, Nkosinathi Makhubela, Hlengilizwe Nyoni, Lawrence Mzukisi Madikizela, Bethusile Rejoice Maseko, Somandla Ncube
The results generally show that sedimentation plays a big role in minimising the concentration of antibiotics within the treatment plant with 83% of the antibiotics reducing their concentrations relative to influent concentrations. As for secondary sedimentation, ampicillin and amoxicillin also had negative removal efficiencies in addition to trimethoprim and penicillin V. The change was insignificant for tetracycline, sulfamethoxazole, sulfapyridine and erythromycin with efficiencies ranging between −7.0 and 9.2%.
Smartphone-based colorimetric determination of sulfadiazine and sulfasalazine in pharmaceutical and veterinary formulations
Published in Instrumentation Science & Technology, 2018
Sophia Ait Errayess, Laila Idrissi, Aziz Amine
Sulfasalazine is a combination of the sulfapyridine antibiotic with 5-aminosalicylic acid. It is an orange powder. The coloring property of this sulfonamide allows its direct determination without using coupling agents. Sulfasalazine was directly determined by spectrophotometry and the developed smartphone camera-based colorimetric analysis without use of chemical reactions.