Phytosomal gel of Manjistha extract (MJE) formulated and optimized with central composite design of Quality by Design (QbD)
Published in Journal of Dispersion Science and Technology, 2023
Mohamad Taleuzzaman, Ali Sartaj, Dipak Kumar Gupta, Sadaf Jamal Gilani, Mohd. Aamir Mirza
Presently, the demand for herbal medicines substantially increases and is accepted by a large population globally due to their fewer side effects and environmentally friendly nature. Herbal medicine in India and south-east Asia used as an indigenous system of medicines (Ayurveda, Unani, Siddha, Chinese, etc.). In other parts of the world, it is treated as complementary and alternative medicines. The herbal products are consumed as dietary supplements or nutraceuticals.[1] Manjistha (Rubia cordifolia Linn.) is a medicinal constituent present in dried roots and stem. It is a good source of anthraquinones and is reported for pharmacological properties like anti-cancer, anti-oxidant, anti-inflammatory, immunomodulatory, and hepatoprotective. It is also extensively used in urinary, blood, and skin disease.[2] Several bioactive compounds have been reported in root extract, including flavonoids, saponins, carboxylic acid, polyphenols, and anthraquinones (e.g., purpurin, mollugin, rubiadin, and munjistin).[3–5]