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Mechanisms of Different Anticancer Drugs
Published in Anjana Pandey, Saumya Srivastava, Recent Advances in Cancer Diagnostics and Therapy, 2022
Anjana Pandey, Saumya Srivastava
Cancer can evade apoptosis, which is an essential factor for tumor progression and resistance to chemotherapy. In patients of chronic lymphatic leukemia (CLL) and acute myeloid leukemia (AML), leukemic cells have shown a higher level of B-cell lymphoma-2 (Bcl-2) protein. Thus, they can avoid apoptosis (Campos et al., 1993; Konopleva et al., 2006; Lagadinou et al., 2013). Research conducted on specific tumor cell lines have shown that by increasing the expression of intracellular Bax protein (Bcl-2-associated-X), these properties of cells can be reversed. Bax induces the proapoptotic factors release from the mitochondria like cytochrome C and can alert the breast tumor cells to anticancer agents or therapies. Pterostilbene (3,5-dimethoxy-4-hydroxystilbene) is a naturally occurring drug having antioxidant properties. It can inhibit the proliferation of cancer cells and tempt apoptosis in breast cancer cells (Moon et al., 2013).
Electrospun membranes of carboxylated poly(ester urethane)urea/gelatin encapsulating pterostilbene for adaptive and antioxidative purposes
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Leilei Zang, Quhan Cheng, Shan Bai, Kai Wang, Xiaoyan Yuan
Pterostilbene (Pte), a dimethylated analogue of resveratrol, is a natural phenolic compound with forceful antioxidant activity for protection of cells from oxidative stress [22–25]. Previous investigations demonstrated that Pte could regulate chronic inflammation caused by atherosclerosis, reduce collagen-stimulated platelet aggregation and modulate vascular smooth muscle cells [26–30]. With two diphenylethylene methoxyls, Pte is a lipophilic compound, and has enhanced stability and higher bioavailability than other kind of stilbene compounds such as resveratrol [22,23,30]. Additionally, hydrophobic Pte can be easily incorporated into a polymer system, but few researches reported the application of Pte in tissue engineered scaffolds although it may be a potential therapeutic agent for preventing or treating vascular diseases and restenosis after angioplasty [27,30].