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Production of Biopigments from Agro-Industrial Waste
Published in Anil Kumar Anal, Parmjit S. Panesar, Valorization of Agro-Industrial Byproducts, 2023
Neegam Nain, Gunjan K. Katoch, Sawinder Kaur, Sushma Gurumayum, Prasad Rasane, Parmjit S. Panesar
Bacteria can be isolated from the environment and purified for the production of pigments. Although extraction of bacterial pigment poses technological challenges, alternative separation techniques can be explored to get purified and concentrated forms of pigments (Venil et al., 2013). Canthaxanthin pigment produced by D. natronolimnaea HS-1 using cheese whey was optimized by Khodaiyan et al. (2008). Cheese whey and yeast extract were shown to improve the production of canthaxanthin (2871±76 g/l) by this bacterium. The use of sucrose and glycine in the medium improved the prodigiosin production by S. marcescens (Su et al., 2011). Violacein production by Dunganella sp. B2 was found to be dependent on concentrations of L-tryptophan, potassium nitrate, and beef extract and the yield was amplified approximately 4.8-fold under optimized conditions (Wang et al., 2009).
Halophilic Microbiome
Published in Ajar Nath Yadav, Ali Asghar Rastegari, Neelam Yadav, Microbiomes of Extreme Environments, 2021
Mrugesh Dhirajlal Khunt, Rajesh Ramdas Waghunde, Chandrashekhar Uttamrao Shinde, Dipak Maganlal Pathak
Microbes isolated from the marine environment produce protein, and purified extract of halophilic protein, that could be a potential source for inhibiting growth and metabolic activities of various pathogenic microorganisms (Rastegari et al. 2019b; Rastegari et al. 2019c; Yadav et al. 2019b; Todkar et al. 2012). Halophilic bacterium Serratia marcescens produced red pigment prodigiosin (Vora et al. 2014). Prodigiosin has a potential application in cancer treatment as it induced apoptosis of human hematopoietic cancer cell lines and no marked toxicity against the non-malignant cell line (Campas et al. 2003) besides use in the treatment of cancer, Halobacterium halobium derived 84 KDa proteinic molecule has been explored for the detection of antibodies against the human cmyc oncogene product in cancer patients (Ben-Mahrez et al. 1988). Thus, many halophilic mediated bioactive compounds possess the potential of effective medicine to cure different diseases and disorders in more liberal ways over different conventional options.
On Biocatalysis as Resourceful Methodology for Complex Syntheses: Selective Catalysis, Cascades and Biosynthesis
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Andreas Sebastian Klein, Thomas Classen, Jörg Pietruszka
The tripyrrole pigment prodigiosin (36), which in addition to its characteristic color is also known for its antibiotic effect against pathogenic microorganisms and antitumor activity. The native producer of prodigiosin is the opportunistically pathogenic bacterium Serratia marcescens. The pig-gene cluster, which comprises the prodigiosin biosynthesis genes pigA to pigN carries the genetic information for the enzymatic production of the monopyrrole MAP (39, 2-methyl-3-amyl-pyrrole) and the dipyrrole MBC (40, 4-methoxy-2,2’-bipyrrole-5-carbaldehyde), which are condensed to the tripyrrole prodigiosin (36) (Hu et al., 2016).
Stochastic modeling and meta-heuristic multivariate optimization of bioprocess conditions for co-valorization of feather and waste frying oil toward prodigiosin production
Published in Preparative Biochemistry & Biotechnology, 2023
Atim Asitok, Maurice Ekpenyong, Ubong Ben, Richard Antigha, Nkpa Ogarekpe, Anitha Rao, Anthony Akpan, Nsikak Benson, Joseph Essien, Sylvester Antai
Serratia species are Gram-negative pink-to-red pigmenting enterobacteria with potentials to elaborate peptidases[10] but only Serratia marcescens strain P3[11] and Serratia sp. HPC 1383[12] have been reported to degrade waste feather. Exploitation of microorganisms in waste feather valorization would be economically more meaningful if one or more value-added metabolites were synthesized during the process.[13] While several species and/or strains have demonstrated potential for commercial prodigiosin and prodigiosin-like compound production,[14,15] no report exists, to date, about Serratia species or any other strain that produces prodigiosin on waste feather substrate. Prodigiosin has been heralded as a versatile biological metabolite with significant applications in health care by reason of its antimicrobial, anticancer/antitumor activities and in industry, owing to its anti-oxidant and free-radical scavenging potentials.[14,15]
2-Keto-D-gluconic acid and prodigiosin producing by a Serratia marcescens
Published in Preparative Biochemistry & Biotechnology, 2021
Hui Xu, Shanshan Wang, Yanjun Tian, Kunfu Zhu, Lei Zhu, Siduo Zhou, Yanhong Huang, Qiangzhi He, Jianjun Liu
Prodigiosin characterized by methoxy pyrrole skeleton structure is the generic terms of a class of natural red pigment. Prodigiosin displayed tremendous potential applications in many fields including pharmaceutical (anti-cancer drugs with little or no toxicity toward normal cell lines), environmental governance (algae growth inhibition) and textile (natural dyestuff) industries.[10–12] In the past, prodigiosin is obtained mainly by plant extracted methods with numerous drawbacks such as instability against light, heat or adverse pH, long period, low water solubility and low yield. With increasing attention to food security, environment and production cost, the traditional plant extracted methods will be gradually replaced, microbial fermentation has gained renewed interest owing to fast growth, low-cost raw materials, independence from weather conditions and different shades of colors.[13] In the nature, many microorganisms such as Streptomyces, Serratia marcescens, Vibrio, Hahella, and Pseudomonas are capable of prodigiosin production.[14] Among the strains mentioned above, Serratia marcescens with powerful capacity ofnatural product production have become the research hotspot for prodigiosin.
Transcriptome analysis reveals that yeast extract inhibits synthesis of prodigiosin by Serratia marcescens SDSPY-136
Published in Preparative Biochemistry & Biotechnology, 2023
Junqing Wang, Tingting Zhang, Yang Liu, Shanshan Wang, Zerun Li, Ping Sun, Hui Xu
Understanding the metabolic network that affects prodigiosin production is critical for guiding the development of industrial strains. Serratia marcescens SDSPY-136 is a high-yield strain that produces prodigiosin.[15] During the cultivation process involving yeast extract, we found that the strain did not produce prodigiosin. In the present study, transcriptome analysis was performed to investigate the role of S. marcescens in the prodigiosin pathway in yeast extract. The purpose of this research was to offer insight into prodigiosin regulation and inform further investigation.