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Bio-Inspired DNA Nanoswitches and Nanomachines: Applications in Biosensing and Drug Delivery
Published in Klaus D. Sattler, st Century Nanoscience – A Handbook, 2020
Arnaud Desrosiers, Alexis Vallée-Bélisle
The third and last reason that makes DNA an ideal polymer for nanotechnology is the simplicity of artificial DNA synthesis that produces DNA sequences in high yield and at a low cost (US$0.05–0.15 per nucleotide) [48]. While there are multiple different methods to synthesize oligonucleotides, the phosphoramidite approach [49] is the most often employed. Its adaptation on solid support allowed to build automated systems for faster and more efficient synthesis [50].
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Published in Chad A. Mirkin, Spherical Nucleic Acids, 2020
Aleksandar F. Radovic-Moreno, Natalia Chernyak, Christopher C. Mader, Subbarao Nallagatla, Richard S. Kang, Liangliang Hao, David A. Walker, Tiffany L. Halo, Timothy J. Merkel, Clayton H. Rische, Sagar Anantatmula, Merideth Burkhart, Chad A. Mirkin, Sergei M. Gryaznov
Oligonucleotides were synthesized using automated solid support phosphoramidite synthesis. Ovalbumin (Sigma-Aldrich) or SIINFEKL (GenScript) were purchased at their highest purity and used as-is without additional purification. The 13 nm Au-SNAs were prepared as described [21] with important modifications and formulated to contain 5.2% (wt/wt) (L-SNA) or 6.3% (wt/wt) (Au-SNA) of oligonucleotide. L-SNAs were synthesized as described [27] with modifications.
Rhodium catalysis in the synthesis of fused five-membered N-heterocycles
Published in Inorganic and Nano-Metal Chemistry, 2020
Navjeet Kaur, Neha Ahlawat, Yamini Verma, Pranshu Bhardwaj, Pooja Grewal, Nirmala Kumari Jangid
Low yields were obtained with terminal alkynes (111) because of a competing alkyne dimerization under initially developed catalytic conditions.[129] The dimerization was prevented with chiral phosphoramidites (114-117) and was found to be the most efficient ligands for the promotion of an enantioselective Rh-catalyzed [2 + 2 + 2] cycloaddition. Poor yields were reported from commercially accessible MonoPhos, while the best enantioselectivities and yields were afforded with Taddol-based phosphoramidites (Scheme 36). The optimization of enantioselectivity was further allowed upon manipulation of the amine portion of phosphoramidite (114-117); ultimately, it promoted the reaction with the highest product enantioselectivities and yields.[130–132]