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Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Pedro Merino, Loredana Maiuolo, Ignacio Delso, Vincenzo Algieri, Antonio De Nino, Tomas Tejero
The use of tri- and dimethylphosphite led to shorter reaction times. Conjugation of a fluorophore to methylester-protected pamidronate (42), prepared from β-aminoacid (39), was carried out in DMSO in the presence of N-methyl morpholine (Scheme 2.13). Methylester-protected pamidronate (42) was obtained without the use of any base or heating within an hour, in two steps, with an overall yield of 91%. The conjugated NIR fluorophore IRDye 800CW N-hydroxysuccinimide ester (43) was performed in the dark at room temperature. Pam800 (45), obtained from hydrolysis of Pam800 methyl ester (44), was used in vivo as contrast agent during image-guided surgery (Bhushan et al., 2007). Reagents and conditions: (i) SOCl2, CH2Cl2, 1 h, reflux. (ii) trimethyl phosphite, toluene, 30 min, 0°C. (iii) dimethylphosphite, Et3N, 30 min, 0–5°C. (iv) DMSO, N-methylmorpholine, 4 h, rt. (v) Me3SiBr, 18 h, rt; (vi) MeOH-H2O (4:1), 30 min, rt. R = IRDye800CW.
Constitution of a Chemical Reaction and Reaction Balancing
Published in John Andraos, Reaction Green Metrics, 2018
(a) phosphorous pentoxide; (b) phosphorus trioxide; (c) phosphorus tetroxide; (d) P4O6; (e) P4O10; (f) phosphorus oxychloride; (g) sodium pyrophosphate; (h) sodium trimetaphosphate; (i) phosphinic acid; (j) phosphoric acid; (k) phosphorous acid; (l) hypophosphorous acid; (m) trimethyl phosphite; (n) dimethyl methylphosphonate
Chemical Terrorist Agents
Published in Robert A. Burke, Counter-Terrorism for Emergency Responders, 2017
The following chemicals are precursors to the production of soman. When any of them are found in an occupancy, and their legitimate use cannot be established, law enforcement should be notified. Ammonium bifluorideDimethyl methylphosphonateDiethylphosphiteDimethylphosphiteHydrogen fluorideMethylphosphonous difluorideMethylphosphonyl dichlorideMethylphosphonyl difluoridePinacolonePinacolyl alcoholPotassium bifluoridePotassium fluoridePhosphorus trichlorideSodium bifluorideSodium fluorideThionyl chlorideTrimethyl phosphite
Recovery of phosphorous from industrial waste water by oxidation and precipitation
Published in Environmental Technology, 2018
Rikard Ylmén, Anna M. K. Gustafsson, Caterina Camerani-Pinzani, Britt-Marie Steenari
The thiosulfate titration of the waste water showed that the phosphorous is mainly present in the form of phosphite, although there is also a small amount of phosphate. Due to the high pH the phosphite was fully deprotonated and thus in the form of doubly negatively charged ions, HPO. The remaining hydrogen atom in the phosphite molecule is bonded to the phosphorous atom and not acidic.