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Facile Chemical Fabrication of Designer Biofunctionalized Nanomaterials
Published in Vineet Kumar, Praveen Guleria, Nandita Dasgupta, Shivendu Ranjan, Functionalized Nanomaterials I, 2020
Successful coupling of proteins andamine-terminated DNA to water soluble nanoparticles using EDC or its derivatives as the main coupling reagent have been functionalized to nanoparticles. Many nanomaterials are fabricated using this strategy for various biomedical applications.EDC chemistry is used to attach methoxypolyethylene glycol amine to carboxylated magnetic nanoparticles. The number of PEG molecules on nanoparticle could be adjusted by varying the ratio of EDC/ nanoparticle. Similarly, Amine-PEG-Amine is coupled on to gold nanoparticle using EDC chemistry (Sanz et al., 2012). PEG molecules possessing –COOH and – NH2 group on their termini could be biofunctiolaized to produce water soluble gold nanoparticle. Maleimide is used to conjugate primary amines to sulfhydryl group. At pH 6.5–7.5, maleimide reacts with thiol group to yield a stable 3-thiosuccinimidyl ether linkage. Maleimide coupling is vastly used to couple various biomolecules on to gold nanoparticles, such as peptides and DNA (Brinkely, 1992).
Progress and Road Blocks in the Development of Carbon Nanotubes as Cellular Carriers for Nucleic Acids
Published in Vladimir Torchilin, Mansoor M Amiji, Handbook of Materials for Nanomedicine, 2011
Bridget D. Dolash, Donald E. Bergstrom
Any of the procedures described above for covalently linking amino groups to carbon nanotubes could in theory be used to covalently link a thiol-derived oligonucleotide by way of a bifunctional crosslinking reagent. This is illustrated in Fig. 18.10 where the amino group was introduced electrochemically by reduction of a nitro group to an amine followed by coupling a maleimide containing active ester to the amino group.10 Maleimide reacts selectively with thiols contained on peptides, proteins, and nucleic acids.
Electron Beam Processing of Rubber
Published in Anil K. Bhowmick, Current Topics in ELASTOMERS RESEARCH, 2008
Rajatendu Sengupta, Indranil Banik, Papiya Sen Majumder, V. Vijayabaskar, Anil K. Bhowmick
The acrylic compounds, maleimides, dimaleimides, and thiols are known as direct cross-link promoters, since they enter directly into the cross-linking reaction and become interconnecting molecular links [243].
Synthesis of substituted N-phenylmaleimides and use in a Diels–Alder reaction: a green multi-step synthesis for an undergraduate organic chemistry laboratory
Published in Green Chemistry Letters and Reviews, 2019
Loyd D. Bastin, Manisha Nigam, Sam Martinus, James E. Maloney, Landon L. Benyack, Brendan Gainer
Additionally, there are two reports of the synthesis of N-(4-chlorophenyl)maleimide directly from maleic anhydride and 4-chloroaniline that are extremely atom efficient (atom economy for both is 92%). Reddy et al. report that the grinding method utilized here results in the maleimide product (88), however, we have been unable to reproduce this result. Le et al. use an ionic liquid to directly synthesize maleimides from an anhydride and aniline (89). While Le’s method is atom efficient, the reaction requires a significantly higher reaction temperature of 140°C and synthesis of the ionic liquid. The synthesis of the ionic liquid requires a wash with THF which negates the low E-factor of the ionic liquid mediated cyclization reaction.