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Bioactive Compounds in agricultural and Food production Waste
Published in Quan V. Vuong, Utilisation of Bioactive Compounds from Agricultural and Food Waste, 2017
Nenad Naumovski, Senaka Ranadheera, Jackson Thomas, Ekavi Georgousopoulou, Duane Mel lor
Flavones: Flavones (Fig. 4b), are most commonly found in the skins of fruits and vegetables as well as in some culinary herbs. Two of the most common flavones in the edible plants are apigenin and luteolin. The apigenin is present in abundance in food sources, such as celery, onion (0.05 mg/100 g) and also in the culinary herbs, such as fresh sage and dried marjoram (4.4 mg/100 g). On the other hand, the luteolin is predominately present in fruit and vegetables, such as celery, broccoli, carrots, cabbages and apple skins at levels up to 60 mg/100 g (Neveu et al. 2010, Naumovski, 2015).
Experimental Study of New Antioxidant to Inhibit Spontaneous Combustion of Coal
Published in Combustion Science and Technology, 2023
Rongkun Pan, Pengyu Wang, Xuefeng Han, Hailin Jia, Jiangkun Chao
Luteolin (LUT), which is chemically known as 3′, 4′, 5, 7-tetrahydroxyflavone, possesses strong biological activity and antioxidant properties (Zhang, Zhang, and Zhong 2005); its structural formula is shown in Figure 1. Luteolin, as one of the most representative flavonoids, has significant free radical scavenging ability because it is easily oxidized. Yan, Li, and Yuan (2006) found that the antioxidant effect of luteolin was comparable to that of the same dose of BHT (dibutyl hydroxytoluene) and better than that of the same dose of tea polyphenols, and the abilities of reduction and hydroxyl removal were both stronger than those of tea polyphenols. In addition, flavonoids have strong ion chelating ability and can complex or participate in redox reactions with a variety of metal and transition metal ions, which can generate new complexes (Cai 2016). Therefore, luteolin has good potential for development as a natural antioxidant.
ESI-TOF MS analysis and DNA cleavage activity of complexes formed by luteolin and five metal ions in hot water
Published in Inorganic and Nano-Metal Chemistry, 2020
Kangkang Zheng, Yunhao Xiong, Zhimin Li, Liang Peng, Qianhui Guo, Xiaojun Li, Xuezhen Deng
Luteolin (structure shown in Figure 1) is one of the most widely distributed flavonoids in nature. It is found in medicinal plants and edible plants such as honeysuckle, mint, peanut, carrot, celery, cucumber, pomegranate, lettuce, and buckwheat.[16,17] Luteolin has been shown to exhibit antioxidant, antibacterial, antiviral, and anti-tumor properties, in addition to cardiovascular and cerebrovascular protection. Since the majority of edible and medicinal plants are ingested after boiling in water, we considered that to study the formation of complexes between luteolin and metal ions in plant decoctions, it was necessary to heat the luteolin with five metal ions commonly found in plants, namely Ca2+, Mg2+, Zn2+, Fe3+, and Cu2+ in water to induce a reaction. The reaction supernatants are tested by electrospray ionization time-of-flight mass spectrometry (ESI-TOF MS), and the exact mass and isotopic distribution are analyzed to determine the types and coordination modes of the luteolin-metal complexes in the reaction products. The reaction products are then subjected to DNA cleavage tests to determine if the formed luteolin-metal complexes exhibit any new biological activity, since for many anticancer drugs, and in particular metal complexes, DNA is the main target.[18,19]
Inhibitory potentials of phytocompounds from Ocimum gratissimum against anti-apoptotic BCL-2 proteins associated with cancer: an integrated computational study
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Gideon A. Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Saheed O. Afolabi, Rotimi J. Ojo, Uju D.I. Ejike, Joseph O. Adebayo
Among the 5 compounds with lowest binding energy, UA, β–Sitosterol and luteolin exhibited high affinity binding to multiple anti-apoptotic proteins. The beneficial effects of UA, which include anti-oxidant, anti-apoptotic, anti-inflammatory, and anti-carcinogenic have attracted special interest [44]. The higher binding tendencies for BCL-2 and BFL-1 by ursolic acid than Gambogic acid is in tandem with several in vitro studies that reports their modulatory effects on this protein. For instance, early report shows that, treatment with ursolic acid led to the down regulation of BCL-2 protein in MCF-7 breast cancer cells [45]. The modulatory effects of β-sitosterol and other phytosterols on the activity of these proteins have been studied in vitro. For instance, phytosterols isolated from the root extracts of Clinacanthus nutans inhibited BCL-2 in MCF-7 cells [46]. Specifically β-sitosterol induced significant reduction of Bcl-2 proteins in MCA-102 fibrosarcoma cells [47]. β-sitosterol elevated the ratio of Bax/Bcl-2 in human U937 cells [48]. A recent studies showed that, other phytosterols such as cycloartenol modified the ratio of Bax/Bcl-2 in glioma U87 cells [49]. Another study demonstrated the Bcl-2 proteins expression reducing effect of stigmasterol in human SNU-1 gastric cancer cell line [50]. Luteolin (3,4,5,7-tetrahydroxy flavone) is a dietary flavonoid found in different vegetables, fruits and medicinal plants. The cancer cells inhibitory activity of luteolin against various preclinical models such as human breast, lung, glioblastoma, prostate, pancreatic, and colon cancers has been widely reported [51]. Luteolin has been reported to inhibit carcinogenesis in vitro and in vivo through various mechanisms which include: protection from carcinogenic stimuli, inhibition of proliferative potential of tumor cells, and activation and promotion of cell cycle arrest, and induction of apoptotic process through different signaling pathways [52]. A recent study showed that the proliferation of the breast cancer cell line (MDA-MB-231) was efficiently suppressed by luteolin in a concentration dependent manner [53]. Luteolin has also been reported to enhance mitochondrial membrane potential collapse and opening of the permeability transition pore with the release of cytochrome c through inhibition of Bcl-2 expression [54].