Digoxin

Digoxin

Digoxin is a medication that belongs to the pharmacological class of cardiac glycosides. It is derived from the leaf of the Digitalis foxglove plant and can be administered orally or by injection. Digoxin acts as a cardiac stimulant, increasing the force of contraction of the heart in congestive heart failure, and also has anti-arrhythmic properties. It is indicated for the treatment of mild-to-moderate heart failure.From: Dictionary of Biomedical Science [2019], The concentration of digoxin after intravenous and oral administration studied by a two-compartment model [2019]

Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics

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Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022

Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan

Digoxin, a cardiac glycoside extracted from Digitalis purpurea (foxglove), is extensively used to treat several heart conditions. It strongly inhibits the expression of viral mRNA in SARS-CoV-2 chikungunya, MERS-CoV, HIV, and other viruses (Cho et al. 2020). In recent years, various studies showed the anticancer effects of digoxin, as individual administration or a combination with other chemosynthetic drugs. It has also been reported to down-regulate the signalling pathways necessary for tumour proliferation in several breast cancer cases (Wang et al. 2020).

The concentration of digoxin after intravenous and oral administration studied by a two-compartment model

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Published in Letters in Biomathematics, 2019

V. Siva Rama Krishna Reddy, K. Lakshmi Narayan

Digoxin: Digoxin is a cardiac glycoside indicated for the treatment of mild-to-moderate heart failure. Most frequently, it is used for atrial fibrillation, atrial flutter and heart failure. Digoxin is taken by mouth or by injection into a vein. Digoxin is extracted from the leaves of Digitalis lanata. The term ‘digitalis’ is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide. Digoxin is described chemically as (3, 5, 12)-3-[O-2, 6-dideoxy--D-ribo-hexopyranosyl-(14)-O-2, 6-dideoxy--D-ribo-hexopyranosyl-(14)-2, 6-dideoxy--D-ribo-hexopyranosyl) oxy]-12, 14-dihydroxy-card-20(22)-enolide. Its molecular formula is , its molecular weight is 780.95, and its structural formula is:

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Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics

The concentration of digoxin after intravenous and oral administration studied by a two-compartment model