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Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Sarwar Beg
The bark of Boswellia (family Burseraceae) having sweet, cooling, and tonic effect and contain boswellic acid resin as the main chemical constituent and it’s 13-form has anti-inflammatory and anti-arthritic activities. Commonly Boswellia is useful in fever, cough, asthma, urethrorrhea, diaphoresis, convulsion, chronic laryngitis, and jaundice and is analgesic, antihyperlipidemic, and anti-atherosclerotic (James et al., 1991). In both adults and children with RA experienced effective relief from the symptoms when treated with Boswellia, despite having responded poorly in the past to standard therapies such as (NSAIDs) (Kimmatkar et al., 2003). In an animal study, Boswellic acid show significantly reduced in the infiltration of leukocytes in the knee joint and in turn, significantly reduced inflammation (Kimmatkar et al., 2003). A clinical study was conducted to assess the efficacy, safety, and tolerability of Boswellia serrata (BS). BS extract was given to the 30 patients of arthritis, 15 each receiving active drug or placebo for 8 weeks founds decrease in knee pain, increase knee flexion, and a decrease in the frequency of swelling in the knee joint (Anthoni et al., 2003).
Emergence of Nanovesicular Systems for Topical Delivery of Natural Bioactives
Published in Bhupinder Singh, Om Prakash Katare, Eliana B. Souto, NanoAgroceuticals & NanoPhytoChemicals, 2018
Gajanand Sharma, Kanika Thakur, Akanksha Mahajan, Guneet Singh Randhawa, Bhupinder Singh, Om Prakash Katare
Boswellic acid (BA) is isolated from oleo gum of Boswellia serrata and employed as a potential anti-inflammatory, hypolipidemic, and anticancer agent. The topical niosomal formulation of BA was developed by Mehta et al. (2016) to improve its poor oral bioavailability. The developed formulation revealed spherical vesicles with a particle size of 707.9 nm and high encapsulation efficiency. The anti-inflammatory activity revealed higher inhibition than the marketed gel, consequently indicating that BA-loaded niosomal gel was better in terms of absorption, bioavailability, and release kinetics.
Terpenoids: The Biological Key Molecules
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Moumita Majumdar, Dijendra Nath Roy
Boswellic acid, a pentacyclictriterpenic acid isolated from Boswellia serrate, has some conventional use in treating diverse kinds of chronic inflammatory diseases such as rheumatoid arthritis (Khanna et al. 2007) and atherosclerosis (Cuaz-Pérolin et al. 2008). A promising study carried out by Syrovets et al. demonstrated that boswellic acid prevented IKKa and IKKb kinases via binding and modulated downstream NF-κB signalling (Cuaz-Pérolin et al. 2008).
Boswellic acids ameliorate doxorubicin-induced nephrotoxicity in mice: a focus on antioxidant and antiapoptotic effects
Published in Egyptian Journal of Basic and Applied Sciences, 2019
Manal M. Sami, Eman A.I. Ali, Rania A. Galhom, Amal M. Youssef, Hala M.F. Mohammad
Boswellic acids (BAs) constitute a promising natural remedy for several diseases due to their antioxidant, anti-inflammatory and anti-neoplastic potentials. They are the extracts of Boswellia serrata (B. serrata) tree, Frankincense, which has a lengthy history of usage in folk medicine in India for their powerful healing effects [13].