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Medical Implications of Stress
Published in J. Rose, Human Stress and the Environment, 2021
The benzodiazepine (BDZ) anxiolytics have proved to be highly effective in the control of anxiety symptoms, but recently the emergence of dependence and withdrawal effects49 have resulted in a precipitous decline in their use. The majority of patients with stress-induced anxiety are treated by their general practitioners and alternative psychological techniques50 are not always appropriate in situations of inadequate time and training. Although new effective anxiolytic drugs are being developed without the hazard potential of the benzodiazepines,51 it may be some time before these are fully evaluated and made available to the clinician. An alternative approach is to use the beta-adrenergic blocking drugs for their anxiolytic properties.52
What do you mean ‘anxiety’? Developing the first anxiety syndrome biomarker
Published in Journal of the Royal Society of New Zealand, 2018
First let us consider a group of drugs that are generally classed by clinicians as ‘anxiolytics’ (i.e. they are used for the treatment of anxiety, as opposed to panic or depression): benzodiazepines; buspirone; and pregabalin. Any one drug in this group may be muscle relaxant, anti-convulsant, headache-inducing, anti-panic, anti-depressant or addictive. But in no case (dark blue arrows) do all three types of anxiolytic produce all these effects; while all are similarly (moderately) effective in treating generalised anxiety disorder (GAD). Importantly, these ‘anxiolytic drugs’ achieve their actions through quite different pharmacological systems: benzodiazepines modulate the GABAA receptor; buspirone modulates the 5HT1A receptor; and pregabalin modulates calcium channels. These pharmacological variations account for the variation in their side-effect profiles; while their common effect on anxiety is the result of a common final action on neural pathways that control anxiety.
UDC: 612.084:636 the effect of 2-oxoindoline-3-glyoxylic acid derivatives on animals’ behavioral and autonomic reactions in the open field test
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Ruslan V. Lutsenko, Oleksiy V. Storozhenko, Antonina H. Sydorenko, Svetlana Yu. Chechotina, Olga A. Lutsenko
Considering the obtained results, it can be suggested that the presence of sedative and anxiolytic activity in the compounds allows positioning them for potential use in the treatment of anxiety disorders, anxiety-neurotic states (emotional lability, memory impairments, decreased concentration and attention), restlessness, fear, obsessive states, as well as for the prevention of stress-related conditions.