China
Africa
Explore chapters and articles related to this topic
Microwave-Assisted Hirao and Kabachnik–Fields Phosphorus–Carbon Bond Forming Reactions
Published in Banik Bimal Krishna, Bandyopadhyay Debasish, Advances in Microwave Chemistry, 2018
α-Aminophosphonates and related derivatives are desirable targets in biochemistry due to their versatile bioactivity of which synthesis and use of such organophosphorus compounds have received great attention during the last two decades. As mimics of natural amino acids and of low mammalian toxicity, the functionalized α-aminophosphonate derivatives are currently attracting a great deal of interest in industrial as well as medicinal chemistry (Bird et al., 1994; Fields, 1999; Giannousi and Bartlett, 1987; Grembecka et al., 2003; Kukhar and Hudson, 2000; Liu et al., 2002; Razaei, 2009; Wuggenig et al., 2011). These compounds are reported to exhibit a variety of biological activities, such as antifungal activity (Ouimette and Coffey, 1989), antibacterial activity (Sonar et al., 2010), antitumor effects (Bloemink et al., 1999; Jin, 2006; Kiran et al., 2008; Koteswara Rao et al., 2011), antiviral activity (Xu et al., 2006), enzyme inhibitors, such as rennin (Allen et al., 1989), HIV, and serine protease (Kafarski and Lejczak, 2001; Siénczyk and Oleksyszyn, 2009), PTP1B inhibitors (Ghotas et al., 2009), and pharmacological agents (Atherton et al., 1968; Kaboudin and Moradi, 2005). Dialkylglycine decarboxylase (Mucha et al., 2011) and leucine aminopeptidase (Grembecka et al., 2003) are also inhibited by α-aminophosphonates. A good number of such compounds have been found to possess effective in vitro growth inhibitory activity against the malaria parasite Plasmodium falciparum (Rawls, 1998), and also against single-celled parasites such as Toxoplasma that causes opportunistic infections in AIDS patients (Roberts et al., 1998). Certain α-aminophosphonates were proved to be suitable for the design of continuous drug release devices due to their ability to increase the membrane permeability of a hydrophilic probe molecule (Danila et al., 2008). Additionally, α-functionalized phosphonic acid esters can serve as synthetic intermediates in phosphonate chemistry for many organic compounds and dyes, and also be used in laser technology and as fluorescent materials for the visualization of biomolecules (Janardhan Rao et al., 2010; Naydenova et al., 2010; Orsini et al., 2010; Veeranarayana Reddy et al., 2007, 2010).
One pot synthesis of bis (dihydropyrimidinone) and tetrahydro-4H-chromenes derivatives using Ag2O/GO/TiO2 composite nanostructure
Published in Inorganic and Nano-Metal Chemistry, 2023
Fatemeh Samandi Zadeh, Mohammad Kazem Mohammadi, Ayeh Rayatzadeh, Neda Hasanzadeh
Graphene oxide (GO), consisting of two carbon sheets with closed lattice structure, has gathered widespread interest as a catalyst and catalytic support due to presence of surface bound active functional sites, large surface area, and excellent thermal and mechanical properties.[1] Primary cause for high activity of GO is the presence of hydroxyl, carboxylic and epoxy groups which shows high acidity, excellent oxidizing properties, good conductivity, and so on.[2–4] Organic transformations are catalyzed by GO utilizing its acidic protons or its strong oxidizing ability showing potential to replace the traditional metal catalyzed pathways. Numerous one pot syntheses such as a-aminophosphonate synthesis, benzimidazole synthesis, epoxidation, Michael addition, aldol condensation and so on, are accelerated by surface bound hydroxyl and carboxylic acid groups in GO.[5–9]