Amino alcohols

Amino alcohols

Catalytic Amination of Alcohols and Its Potential for the Synthesis of Amines

Published in John R. Kosak, Thomas A. Johnson, Catalysis of Organic Reactions, 2020

In addition to the production of aliphatic amines, catalytic amination can be used for the synthesis of various other chemicals, including amino alcohols, diamines, enamines, cyclic amines, and imines. The potential of catalytic amination of alcohols, diols, and poly alcohols has not been exploited so far, and several possibilities for amine synthesis are waiting to be explored. Of particular interest could be the use of catalysts which contain active sites both for alcohol synthesis from carbon oxides and hydrogen and for catalytic amination. Such multifunctional catalysts could further expand the potential of catalytic amination for the synthesis of amines.

Amino acids: Building blocks for the synthesis of greener amphiphiles

View Article

Journal Information

Published in Journal of Dispersion Science and Technology, 2018

Nausheen Joondan, Sabina Jhaumeer Laulloo, Prakashanand Caumul

Amino acidbased surfactants containing chiral amino alcohols are important in asymmetric and pharmaceutical synthesis.[65] Amino alcohols are obtained by the reduction of amino acid esters with sodium or lithium aluminium hydride or sodium borohydride. Methylation of reduced amino acids using a mixture of formic acid/formaldehyde gave the N,N-dimethyl derivatives, which upon reaction with alkyl halides of varying chain lengths gave the optically active QUATS 55 and 56.[66,67] Reaction of N-dimethyl phenylalaninol with dodecanoyl chloride followed by methyl bromide in acetonitrile yielded the surfactant 57 (Figure 14) in which the hydrophobic tail was attached to the alcohol moiety via an ester linkage.[68]

Explore chapters and articles related to this topic

Catalytic Amination of Alcohols and Its Potential for the Synthesis of Amines

Amino acids: Building blocks for the synthesis of greener amphiphiles