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Clinical Toxicology of Mercury
Published in Debasis Bagchi, Manashi Bagchi, Metal Toxicology Handbook, 2020
Sonal Sekhar Miraj, Pooja Gopal Poojari, Girish Thunga P, Mahadev Rao
Alpha-lipoic acid (ALA) has showed beneficial effect in Hg poisoning by increasing levels of glutathione intracellularly to promote the mobilization and elimination of Hg (Patrick 2002). Additionally, ALA protects against cellular damage and neurotoxicity. Dihydrolipoic acid (DHLA), a reduced ALA form, seems to possess direct heavy metal-binding action. While comparing with dithiol-chelating agents (DMSA, DMPS, etc.), ALA has the ability to bind as well as mobilize heavy metals from tissue, however, with lesser effect. On the other hand, upturns in levels of glutathione with administration of ALA are not just from the conversion of oxidized glutathione to reduced form, but also from the glutathione synthesis (Packer et al. 1997). DHLA, a potent antioxidant has the ability to restore glutathione, vitamin E, oxidized ascorbate and coenzyme Q (Queiroz et al. 1998), and in addition to attribute the ability of ALA to promote levels of intracellular glutathione.
Nanonutraceuticals in Central Nervous System Disorders
Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019
Amita Sarwal, Nisha Rawat, Gurpreet Singh, V. R. Sinha, Sumit Sharma, Dinesh Kumar
It is also known as α-Linolenic acid (ALA), transformed into eicosapentaenoic acid (EPA) and eventually into docosahexanoic acid (DHA). Even as n-6 PUFA is called linoleic acid, it endogenously gets converted into arachidonic acid (AA), which is a precursor of pro-inflammatory and eicosanoids compounds (Stillwell and Wassall, 2003). n-3 PUFAs antioxidant property is useful for cognitive improvement, synaptogenesis, and synaptic transmission.
Co-production of biodiesel and alpha-linolenic acid (omega-3 fatty acid) from microalgae, Desmodesmus sp. MCC34
Published in Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, 2018
Senthil Nagappan, Sanjay Kumar Verma
Alpha-linolenic acid (ALA) is a highly valued omega-3 fatty acid and a pharmaceutically important compound. The ALA, an essential fatty acid that has a hypocholesterolemic effect, hypolipidemic activity, anti-inflammatory effect, and antidepressant effect, offers neuroprotection, known to prevent secondary coronary infection, and reduces roughness and scaling of skin (Barceló-Coblijn and Murphy 2009; Kim et al. 2014). Major dietary source of ALA is flaxseeds which contain 53% of ALA followed by rapeseed, soybean, and sunflower with 9, 7, and 1% of ALA in their fatty acid, respectively. Apart from dietary intake, Mortierella isabellina is reported to synthesize 8% ALA under heterotrophic condition (Xian et al. 2002). The ALA has also been synthesized artificially by using phosphonium salt (Kim et al. 2014). In this scenario, microalgae which grow phototrophically can be an alternate source of ALA along with biodiesel production. Previous studies suggest that the microalgae have been tried as an alternate source of omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid (Adarme-Vega et al. 2012; Guihéneuf et al. 2009; Mitra, Patidar, and Mishra 2015), but the commercial production of ALA in microalgae has not been investigated. In this study, an attempt has been made to explore the possibility of co-production of ALA along with other fatty acid methyl esters (FAMEs) that can be used for biodiesel production.
Spray-dried almond milk powder containing microencapsulated flaxseed oil
Published in Drying Technology, 2022
Federico Bueno, Alexander Chouljenko, Vondel Reyes, Subramaniam Sathivel
Flaxseed oil (FO), an emerging oil source, is a vital nutraceutical/functional food that contains high amounts of α-linolenic acid (ALA) (ω-3) (C18:3). High levels of this essential fatty acid can benefit babies and adults, such as reducing cardiovascular diseases, diabetes, cancer, and neurological disorders. The consumption of ALA is essential since the body cannot produce it. ALA is a precursor of other omega 3 fatty acids such as eicosapentaenoic acid (EPA) (C20:5) and docosahexaenoic acid (DHA) (C22:6). The consumption of essential oils and omega 3 fatty acids is fundamental for the growth and development of young children and may help reduce LDL cholesterol and cardiovascular disorders in adults.[2]
Predominant role of antioxidants in ameliorating the oxidative stress induced by pesticides
Published in Archives of Environmental & Occupational Health, 2021
Srujana Medithi, Padmaja R. Jonnalagadda, Babban Jee
Administration of ALA to rats along with Dimethoate (OP), Glyphosate (OP) and Zineb (fungicide) displayed the protective role of ALA against pesticide induced damage. The study suggests that the administration of ALA can also be a promising therapeutic strategy with reference to brain disorders.81