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Drug Development
Published in Mihai V. Putz, New Frontiers in Nanochemistry, 2020
Corina Duda-Seiman, Daniel Duda-Seiman, Mihai V. Putz
Modified fullerene (diadduct malonic acid-fullerene-Asn-Gly-Arg peptide [DMA-C60-NGR]) and 2-methoxyestradiol (2ME) exhibit an increased inhibition (antiproliferative) effect in the estrogen receptor-positive human breast adenocarcinoma cell line (MCF-7). 2ME induces apoptosis in some tumor cells, but not in normal cells, via several mechanisms: tubulin depolymerization, upregulation of p53 and death receptors, as well as the production of ROS (reactive oxygen species) (Shi et al., 2013).
Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies
Published in Journal of Toxicology and Environmental Health, Part B, 2023
Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, João Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Felipe Cavalcanti Carneiro da Silva
For in vitro cytotoxicity assays, the chemotherapeutics and other pharmacological agents most frequently used in association with BSO were: Natural products (n = 19) and antibiotics (n = 12): arsenic trioxide (ATO), L-asparaginase, sesquiterpene lactones, SN-38 (active metabolite of irinotecan), hydroxychavicol, etoposide, vincristine, ferrous gallic acid, paclitaxel, eupatoriopicrin, menadione, helenalin, doxorubicin, daunorubicin, mitomycin C, actinomycin;Alkylating agents (n = 15) and platinum analogues (n = 12): melphalan (L-PAM), carmustine (BCNU), temozolomide, cisplatin (CDDP), cyclophosphamide (CFA), nitrogen mustard, iproplatin, oxaliplatin;Antimetabolics (n = 4): 5-fluorouracil, gemcitabine, azathioprine;Other pharmacological agents (n = 39): auranofin, erlotinib, perifosine, protoporphyrin Zn(II), arsenic disulfide, sahaquin, photosensitizers (chlorine e6, phthalocyanine aluminum disulfonate), sulindac sulfide, ATN-224, misonidazole, 2-deoxyglucose (2DG), organometallic complexes, 17 -(allylamino)-17-demethoxygeldanamycin (17AAG), TNF-α, fenretinide, gold nanoparticles, erastine, calcitriol, sodium butyrate, 3-bromopyruvate, inhibitors of antioxidant molecules (2-methoxyestradiol, 3-amino-1,2,4-triazole, diethylmaleate), L-dopa, naphthols, prednisolone, metallointercalators, MRP1 modulator, nifurtimox, hydroquinone, N-acetyl-4-S-cysteaminylphenol (NA-CAP).