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Cancer Incidence and Mortality: In India and Worldwide
Published in Anjana Pandey, Saumya Srivastava, Recent Advances in Cancer Diagnostics and Therapy, 2022
Anjana Pandey, Saumya Srivastava
In 2020, around 21,750 new cases and 13,940 deaths of ovarian cancer were reported, accounting for 1.2% of total cancer cases. The 5-year survival rate of ovarian cancer is projected to be 48.6%, among which 15.7% of ovarian cancers are locally staged and 58% are at the metastasis stage. If cancer is detected early, the 5-year survival rate slopes down to 30.2% from 92.6% (Modugno and Edwards, 2012; Momenimovahed et al., 2019; Mancari et al., 2020).
Detecting collagen fibrils’ structure in ovarian cancer using second harmonic generation microscopy
Published in Khaled Habib, Elfed Lewis, Frontier Research and Innovation in Optoelectronics Technology and Industry, 2018
Jun-Fang Wu, Xi-Da Li, Chao Li
Ovarian cancer is the leading cause of death of all gynecologic cancers. Early ovarian cancer usually has no obvious symptoms, which is why the disease is typically diagnosed at an advanced stage. Women diagnosed with localized-stage ovarian cancer have more than a 90% five-year survival rate. For late-stage ovarian cancer, the five-year survival drops to 29%. Therefore, early detection of this disease is very important in order to improve the survival rate.
Imaging of the genitourinary tract
Published in Sarah McWilliams, Practical Radiological Anatomy, 2011
o It is also used to assess the ovaries for masses, diagnosis of ovarian cancer, ovarian cyst assessment, family history screening for ovarian cancer, infertility treatment assessing follicular size and in diagnosis of ectopic and early pregnancy. The diagnosis of ovarian cancer still involves clinical examination and CA-125 levels.
Investigation of characterization and cytotoxic effect of PEGylated nanoliposomal containing Melphalan on ovarian cancer: an in vitro study
Published in Journal of Experimental Nanoscience, 2021
Seyedeh Masoomeh Sadat Mirnezami, Amir Heydarinasab, Azim Akbarzadeh, Mehdi Arjmand
There are various approaches, such as chemotherapy, radiotherapy, and surgery, for the treatment of cancers [5]. Chemotherapy, radiotherapy, and surgery are some of the most common treatments for ovarian cancer. Since anticancer drugs are not an option in chemotherapy, high doses of these drugs are often needed to achieve the desired level of treatment in tumor tissues. Also, as anti-neoplastic drugs have a high molecular weight and a high volume of distribution, the use of high doses of the drugs causes healthy tissues to be exposed to these drugs, and thus, the toxicity of the drug increases [6]. In addition, using anti-neoplastic drugs to treat cancers is associated with a wide range of side effects and deficiencies, such as non-specificity, short half-life, and multi-drug resistance (MDR) [6,7]. MDR has been considered as one of the most important obstacles to successful chemotherapy. Therefore, to minimize these side effects and shortcomings, efforts have been made to develop targeted drug delivery systems.
Anion-directed synthesis of two Cu(II)-based coordination polymers: biological evaluation and mechanism against the ovarian cancer
Published in Inorganic and Nano-Metal Chemistry, 2022
Xiao-Yu Yu, Yu-Ling Liu, Lu-Yang Wang, Jing-Ying Bai, Qian-Nan Li
Ovarian malignant tumor is a relatively common malignant tumor in female gynecology, accounting for 2%–6% of common malignant tumors in women. Its incidence is second only to cervical cancer and endometrial cancer.[1] For ovarian cancer, surgery combined with chemotherapy is still the main treatment method, and satisfactory tumor reduction during initial treatment is the most important independent prognostic factor for ovarian cancer.[2] However, the ideal cytoreductive surgery in China is only about 10%–20%. In recent years, carboplatin-based chemotherapy and paclitaxel chemotherapy could reduce the mortality rate of ovarian cancer, but the decrease is not significant.[3]
Two Cu(II)-based coordination polymers: inhibitory activity on the ovarian cancer cell invasion and migration by regulating the miRNA16 expression
Published in Inorganic and Nano-Metal Chemistry, 2022
Dong-Mei Yang, Li-Hong Huang, Qiong Xia, Ai-Ling Li, Yu Chen
Ovarian cancer is a malignant tumor of the reproductive system that seriously threatens women's lives. In 2012, there were 22,280 new cases in the United States.[1] Ovarian cancer is insidious and lacks early diagnosis measures and effective treatment methods. miRNA is a newly discovered small non-coding RNA with a length of 19–25 nucleotides that regulates gene expression in many eukaryotes.[2] miRNA can regulate a variety of physiological and pathological processes. This year's research shows that miRNAs are involved in the pathological processes of ovarian cancer, such as the cancer occurrence, development, metastasis, and tumor resistance.[3]