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Mathematical Model to Avoid Delay Wound Healing by Infinite Element Method
Published in Jyoti Mishra, Ritu Agarwal, Abdon Atangana, Mathematical Modeling and Soft Computing in Epidemiology, 2020
Manisha Jain, Pankaj Kumar Mishra, Ramakant Bhardwaj, Jyoti Mishra
In the wound-healing process, wound bed preparation is an important phase because it creates an optimal wound-healing environment. Timely healing of wound depends on the preparation of wound bed; the wound bed depends on body temperature and atmospheric temperature: For the temperature of outside temperature, the wound bed temperature can be controlled by proper cleansing and dressing of wounds from time to time.
Topical negative-pressure wound therapy: emerging devices and techniques
Published in Expert Review of Medical Devices, 2020
Raymund E. Horch, Ingo Ludolph, Wibke Müller-Seubert, Katharina Zetzmann, Theresa Hauck, Andreas Arkudas, Alexander Geierlehner
With an increasing life span and sociodemographics changing accordingly, our society is faced with more elderly and multimorbid patients suffering from chronic and non-healing wounds [1]. In addition, surgical site infection (SSI) has become an increasingly relevant issue [2]. Therefore, the reduction of complication rates and the number of treatments as well as the optimization of wound healing and the prevention of SSI have become of utmost importance [3–6]. Since the mid-1990s, negative-pressure wound therapy (NPWT), also known as ‘vacuum therapy’, has emerged as a major advancement in the treatment of complex and chronic wounds as well as in the prevention of wound break down when applied over a closed incision (ci-NPWT) [6,7]. The device consists of a specialized pump system delivering an intermittent or continuous sub-atmospheric pressure. It is connected to a resilient, reticulated open-pore foam-surface dressing covered with an adhesive drape to maintain a closed environment. A canister connected to the computer-controlled pump then collects wound exudate. Later developments incorporated the possibility to add saline or antiseptic solutions through a separate line to the wound bed [8]. It is set to a variable ‘dwell time’ and enables the removal of the solution automatically after a preset period of time. This was considered a major breakthrough allowing the removal of wound debris and the reduction of microbial load and thus promote wound bed preparation [9,10]. It became a standard procedure especially in complex and multistage reconstructions [11]. Although there is a huge body of evidence in the literature supporting the use of NPWT, the majority of studies are based on clinical observations, case series, cohort studies, and sometimes weakly powered randomized controlled trials, which constitute a substantial number of publications with an overall low degree of evidence. Argenta et al. were among the first study group to repeatedly show its successful clinical application followed by McCallon et al. in 2000 assessing the effectiveness of negative pressure on diabetic foot ulcers in a randomized controlled clinical setting [12,13].