Formulation and characteristic evaluation of tacrolimus cubosomal gel for vitiligo
Published in Journal of Dispersion Science and Technology, 2022
Sanjana A, Mohammed Gulzar Ahmed, B.H. Jaswanth Gowda, Suprith Surya
Vitiligo is an acquired idiopathic dermatological disorder characterized by the selective loss of melanocytes, that is, hypomelanosis.[1,2] About 85–95% of the symmetrical lesion’s cases represent non-segmental vitiligo whereas unilateral lesions commonly appear in segmental vitiligo. Younger people more prone to get segmental vitiligo when compared to non-segmental vitiligo.[3] Etiology of vitiligo is unknown, it may be due to lack of immunity power and reduction of melanocyte count in the skin , family history (heredity) or externals factors such as sunburn, stress or exposure to industrial hazards,[4] which results in the smooth, non-scaly, chalky-white macules found in several tissues in the skin, hair follicles, eyes, and inner ear.[5] The prevalence rate of vitiligo is about 0.5–1% of the world population.