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Study of Machine Learning Classification Algorithms to Predict Accuracy and Performance of Liver Disease
Published in Rajesh Singh, Anita Gehlot, P.S. Ranjit, Dolly Sharma, Futuristic Sustainable Energy and Technology, 2022
Pawan Kumar Singh, Virendra Pal Singh, Pankaj Sharma, Durgesh Narayan
The situation in which the liver is infected and does not work in proper order is name as liver disease [2]. There are various reasons which can cause liver diseases. Some of the top causes which lead to serious liver conditions are mentioned below: Infections: An infection can sometimes harm the liver. Viral hepatitis including hepatitis A, B and C is the most frequent infection.Immune system difficulties: These problems happen when the body’s immune system is disordered and attacks the liver. Hepatitis autoimmune, bile cholangitis main and primary cholangitis are causes of the inflammation of the liver.Cancer and tumours: Liver cancer (sometimes called hepatocellular carcinoma), cancer of the bile duct, liver cell adenoma is some of the malignancies that cause substantial liver damage.Conditions You Inherit: Some of the disorders in a person are inherited from his parents. Hemochromatosis, Hyperoxaluria, Wilson’s disease, Alpha-1 antitrypsin deficiency are such inherited disorders which can cause liver diseases.Other Causes of Liver Disease: Alcohol abuse, drug overdoses, non-alcoholic fatty liver disease (NAFLD) are some other reasons which can inflame the liver
Tissue Engineering and Application in Tropical Medicine
Published in Rajesh K. Kesharwani, Raj K. Keservani, Anil K. Sharma, Tissue Engineering, 2022
Viral hepatitis is an important group of infection. The main affected organ in this viral infection is liver. Several hepatitis viruses can cause hepatitis. The good examples are hepatitis A virus, hepatitis B virus, and hepatitis C virus. In tropical developing countries, the hepatitis virus infection is common and becomes the big local public health problem. Some specific kinds of viral hepatitis, especially for hepatitis B and hepatitis C, it can result in chronic liver pathology. The impairment of liver cells can be seen and this can further result in hepatitis failure, cirrhosis, or malignant transformation. The liver fibrosis is common in chronic hepatitis viral infection. The deterioration of liver function in chronic viral hepatitis is common and becomes important problem in infected patients. To manage the chronic viral hepatitis, it is usually difficult and requires good investigation. Similar to the case of using tissue engineering for regenerative therapy for brain pathology in Japanese encephalitis, the role of tissue engineering in regeneration of liver tissue problems, especially for fibrosis, in chronic viral hepatitis can be expected (Köhn-Gaone et al., 2016). In addition, engineered liver model can be useful in novel drug discovery (Lin et al., 2015).
Large-scale purification of recombinant hepatitis B surface antigen from Pichia pastoris with non-affinity chromatographic methods as a substitute to immunoaffinity chromatography
Published in Preparative Biochemistry and Biotechnology, 2018
Seyed Nezamedin Hosseini, Amin Javidanbardan, Behnaz Sadat Alizadeh Salim, Maryam Khatami
Immunization with the vaccine is the most effective way to prevent viral hepatitis B.[1] The first generation of hepatitis vaccine was purified from the plasma of the carriers.[2] However, this method of vaccine production was discarded due to the limited resources of the plasma and the risk of spreading the virus.[3,4] Via recombinant DNA technology technique, the gene of rHBsAg has been expressed in different host cells of prokaryote, yeast, Chinese hamster ovary (CHO), insects and plants.[5–9] Among these host cells, P. pastoris provides an efficient and inexpensive heterologous system for the production of high-level functionally active rHBsAg.[9–13]