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Translation of Tissue Engineering Approach from to Clinics
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Daniel Chavarría-Bolaños, José Vega-Baudrit, Bernardino Isaac Cerda-Cristerna, Amaury Pozos-Guillén, Mauricio Montero-Aguilar
Translational research refers to all the steps needed for bringing the concept of an idea to advanced preclinical and clinical testing and, ultimately, to the development of new therapies for patients (Chen et al. 2012; Ungerleider and Christman 2014). As it can be exemplified (Fig. 2.1a), every new invention rises from a clinical need, and depending on the context, this clinical need can have different origins. In most cases, the main source of a clinical need is the patient itself who presents a certain disease or condition. Usually if there is an effective treatment available, the clinician will treat the patient with the existing approach; but, if this treatment is not ideal or could be enhanced, then the clinician should look for an alternative treatment. Some of the available ‘novel’ therapies may not fit every single case or may lack enough evidence to assure a safe and effective outcome. In such cases, the clinician may finally consider, once again, the traditional strategy. Of course, this will drag the limitations or side-effects already known, and the clinical need may still be unsatisfactory.
A Way Forward
Published in Ashutosh Kumar Dubey, Amartya Mukhopadhyay, Bikramjit Basu, Interdisciplinary Engineering Sciences, 2020
Ashutosh Kumar Dubey, Amartya Mukhopadhyay, Bikramjit Basu
Translational research, as a concept, was introduced in medicine originally, and was defined as bench-to-bedside research. It became an acronym for cross-disciplinary and cross-sectorial research, involving exchange and co-creation of new knowledge. Translational research aims to combine disciplines, resources, expertise, and techniques to empower and enrich researchers with interdisciplinary concepts, and to build a sustainable knowledge-based society. The key requirements of translational research are reorganization of academic teams with cross-disciplinary, cross-sectorial, and cross border co-operation and use of such platforms for perpetual and circular knowledge exchange between researchers and techno-socio-economic stakeholders. Therefore, innovation communities are needed to achieve an environment that allows and nurtures the integration of the best existing knowledge required to build a successful translational research ecosystem.
Valuing and validating
Published in Celia Lury, Rachel Fensham, Alexandra Heller-Nicholas, Sybille Lammes, Angela Last, Mike Michael, Emma Uprichard, Routledge Handbook of Interdisciplinary Research Methods, 2018
Translational research (also routinely referred to as ‘bench to bedside’ research within the medical field) is the term applied to the movement or translation of ‘basic research’ (often produced in the laboratory) into the clinical domain where it can serve as the basis for innovations that are therapeutically, diagnostically and/or preventively useful. According to Watts (2010), translational research has become a key policy priority, shooting ‘up the (UK medical research) agenda’ (n.p.) and being championed by the likes of the Office for Strategic Co-ordination of Health Research, Medical Research Council, and the Academy of Medical Science. It is also central to the funding initiatives of the European Commission’s 7th Framework Programme and US National Institutes of Health (the latter calling for bids for Centres of Excellence of Translational Research).1
Trends in research participant categories and descriptions in abstracts from the International BCI Meeting series, 1999 to 2016
Published in Brain-Computer Interfaces, 2019
Brandon S. Eddy, Sean C. Garrett, Sneha Rajen, Betts Peters, Jack Wiedrick, Deirdre McLaughlin, Abigail O’Connor, Ashley Renda, Jane E. Huggins, Melanie Fried-Oken
Translational research involves studies which bridge basic science with clinical applications to end-users. Kübler and colleagues [8, 26] suggested that the BCI field faces a translational gap or a lack of studies investigating the problems and obstacles that emerge when BCI systems are used by PWD. Kübler [27], indicated that 470 studies on BCI were published from 2008 to 2010, yet only 39 of those studies included people with severe motor impairments. There are many possible factors contributing to this translational gap in BCI research, such as signal reliability concerns for participants with disabilities resulting from multiple sources of signal artifact, as well as fluctuating health and variability in fatigue or medication use [8, 26]. Since these factors are likely to influence user performance, researchers may choose to study participants without disabilities to control for such variables. Kübler [27] also described access to PWD, time requirements for data acquisition, costs, and vulnerability of the target group as additional potential barriers. While the presence of a translational gap was investigated by Kübler [27], from 2008–2010, it is unclear whether the gap was only present for that time period, and further, if it was related to publication bias. No studies to date have yet examined if such a translational gap existed before or after 2008–2010, nor documented change in research participation of PWD over time. If a translational gap is present, quantifying and understanding the gap is the first step to reducing it.
Good management practices of venomous snakes in captivity to produce biological venom-based medicines: achieving replicability and contributing to pharmaceutical industry
Published in Journal of Toxicology and Environmental Health, Part B, 2021
Lucilene Santos, Cristiano Oliveira, Barbara Marques Vasconcelos, Daniela Vilela, Leonardo Melo, Lívia Ambrósio, Amanda da Silva, Leticia Murback, Jacqueline Kurissio, Joeliton Cavalcante, Claudia Vilalva Cassaro, Luciana Barros, Benedito Barraviera, Rui Seabra Ferreira
The translational research paradigm depicts the stages involved in the process of discovering a concept from the basic science perspective and implementation of such knowledge in clinical practice, aiming ultimately to yield public health improvements (Choi, Tubbs, and Oskouian 2018). In view of this scenario, the development of new drugs from candidate biomolecules might generate a bias that may completely render research impossible, even those already in advanced clinical trials. Thus, the production of biodrugs using animal venom as raw material, from the performance of concept tests to synthesis of quality pilot batches, may encounter many errors, since most of the venoms used in this research area are of unknown origin or quality.
Investigating orthodontic tooth movement: challenges and future directions
Published in Journal of the Royal Society of New Zealand, 2020
Fiona A. Firth, Rachel Farrar, Mauro Farella
Translational research involves the application of findings from in vitro and in vivo studies to enhance human well-being. There is potential, with further advances in OTM research, for applications such as the detection of biomarkers or acceleration of tooth movement to be developed. Numerous challenges exist with regard to translational research, including obtainment of funding to conduct the necessary basic science research to advance knowledge of OTM.