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Translational Challenges
Published in Carla Vitorino, Andreia Jorge, Alberto Pais, Nanoparticles for Brain Drug Delivery, 2021
Bárbara Rocha, Nelson Pacheco Rocha, Bruno Gago
The concept of translational medicine was first mentioned in the 1990’s - but only gained consistency in the early 2000’s-as a consequence of the urgency to optimise drug development processes and transform laboratory findings in useful clinical tools. Translational medicine is generally recognised as a multidisciplinary branch of biomedical research which aims to transfer basic research knowledge to clinical practice - from bench-to-bedside - to improve diagnosis, treatment, and prevention of human disease [1]. In the process, findings from molecular biology are applied in the discovery of novel treatment strategies and integrated within clinical trials, leading to the introduction of therapeutic innovation in a continuous bidirectional flow of information.
Health Informatics for Research Applications of CAD
Published in de Azevedo-Marques Paulo Mazzoncini, Mencattini Arianna, Salmeri Marcello, Rangayyan Rangaraj M., Medical Image Analysis and Informatics: Computer-Aided Diagnosis and Therapy, 2018
Translational medicine aims at transferring results from novel research immediately out of the laboratory to improve patient treatment and health care, that is from bench to bedside (B2B). This holds for drugs as well as medical devices. Figure 21.1 visualizes the steps required to transform research to patient benefit, and clinical trials are a central component here.
Graphene-based composites for biomedical applications
Published in Green Chemistry Letters and Reviews, 2022
Selsabil Rokia Laraba, Wei Luo, Amine Rezzoug, Qurat ul ain Zahra, Shihao Zhang, Bozhen Wu, Wen Chen, Lan Xiao, Yuhao Yang, Jie Wei, Yulin Li
In this paper, we summarize the characteristics, production processes, and functionalisms of the graphene and its derivatives as central element for composites in general and biomaterials in particular. Graphene may be concluded as altering nanomaterials in a number of disciplines of science, medicine, and engineering with intriguing possibilities. As described above, it has other important characteristics such as its chemical stability, biocompatibility, broad surface area, ability to operate with different functionalities, excellent mechanical properties (both adaptability and steadiness), and external characteristics, which is nearly 200% times stronger than steel and exhibit an extremely high electric conductivity. Thanks to these features, GBCs increase their attention and give additional opportunities for study and development in translational medicine applications. The biomedical application is based on their mechanical, thermal, and electrochemical characteristics, concerning GBCs specific physiological characteristics. Many publications have utilized GBCs in cancer treatment as well as photo-thermal therapy and photodynamic therapy, gene/drug administration, and anti-infection.
Clinical translation of the assets of biomedical engineering – a retrospective analysis with looks to the future
Published in Expert Review of Medical Devices, 2019
Yijin Ren, Paul H. Fagette, Connie L. Hall, Herman Broers, David W. Grainger, Henny C. Van Der Mei, Henk J. Busscher
The age of the giants was characterized by multi-disciplinary teams of mono-disciplinary trained specialists. A main educational question for a long time has been how to foster and institutionalize innovation and enhance the translational process [1,53,54]. Past successes of the multi-disciplinary teams in the age of the giants have inspired and stimulated development of diverse multi-disciplinary education programs. However, multi-disciplinary trained researchers do not replace the absence of clinicians in a team, nor does multi-disciplinary training provide specialists with the necessary deep knowledge and expert insight in their specific domain: mono-disciplinary trained specialists know a lot about almost nothing, but a multi-disciplinary trained scientist knows almost nothing about a lot. In modern medical education, the role of science and engineering in translational medicine is acknowledged by training physician-scientists or doctor-engineers, but without filling the deep knowledge and expert insight gap in absence of mono-disciplinary trained specialists [55–57].
Vertebral corners detection on sagittal X-rays based on shape modelling, random forest classifiers and dedicated visual features
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2019
Shahin Ebrahimi, Laurent Gajny, Wafa Skalli, Elsa Angelini
Elsa Angelini is the lead senior data scientist for the newly created Institute of Translational Medicine and Therapeutics (ITMAT) within NIHR Imperial Biomedical Research Centre (BRC). She is also affiliated with the Heffner Biomedical Imaging Laboratory at Columbia University and the Department of Image-Data-Signal at Telecom ParisTech. She is a Senior Member of IEEE, and is the current vice-president for Technical Activities for IEEE EMBS (2017-19). Her research interests include: Image and signal processing, computer vision, computer graphics and scientific visualization; clinical applications related to multidimensional imaging modalities for de-noising, enhancement and segmentation; assessment of image quality for different clinical protocols and diagnostic applications; quantification of anatomical structures and physiological functions and validation with clinical studies.