China 
Africa 
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Host Response to Biomaterials
Published in Claudio Migliaresi, Antonella Motta, Scaffolds for Tissue Engineering, 2014
Sangeetha Srinivasan, Julia E. Babensee
higher biomaterial-adherent FBGCs and fibrous capsules twice as thick compared to wild type controls.23 Furthermore, MMP-9 has also been shown to be important in MOs fusion as MMP-9 knockout mice implanted with mixed cellulose acetate or polyvinyl alcohol (PVA) sponges displayed lower extents of FBGC formation.17 In addition, there is evidence that the FBR is compromised in the absence of supplementary wound microenvironment components, specifically, matricellular proteins such as thrombospondin-2 (TSP-2)24 and secreted protein, acidic and rich in cysteine,25 implying their key roles in the progression of the response.
Core genes in lung adenocarcinoma identified by integrated bioinformatic analysis
Published in International Journal of Environmental Health Research, 2023
Liu Yang, Qi Yu, Yonghang Zhu, Manthar Ali Mallah, Wei Wang, Feifei Feng, Qiao Zhang
Studies have found that secreted phosphoprotein 1 (SPP1) plays an important role in different cancers (Ramchandani and Weber 2013; Xu et al. 2017). In order to prevent LUAD progression, some researchers also derived that the proteolytic activation of SPP1 was inhibited by the binding of follistatin-like protein 1 (FSTL1) to pro-SPP1 (Chiou et al. 2019). One genome-wide analysis (Shen et al. 2019) showed that the expression of SPP1 was higher in LUAD tissues than that in adjacent tissues, and SPP1 was responsible for poor prognosis. Zhang Y et al. have emphasized the importance of SPP1 in the regulation of macrophage polarization and immune escape, which may become the therapeutic target for lung cancer (Zhang et al. 2017). In our study, it was found that SPP1 was upregulated in LUAD tissues, associated with the immune infiltration levels, and related with poor prognosis in LUAD patients. Collagen type I α1 (COL1A1), the primary component of type I collagen, is expressed aberrantly in many tumors. One study has found that COL1A1 was overexpressed in hepatocellular carcinoma and associated with poor prognosis (Ma HP et al. 2019) . Jun Li et al. reported that COL1A1 was highly expressed in gastric cancer tissues than normal gastric tissues and related to low overall survival (Li et al. 2016). Urszula Oleksiewicz et al. revealed that COL1A1 in NSCLC was highly expressed and correlated with hypoxia markers (Oleksiewicz et al. 2017). However, the clinical significance of COL1A1 in LUAD remains to be well studied. Thrombospondin 2 (THBS2) belongs to the thrombospondin family. In recent years, THBS2 has been considered as a novel biomarker in variety of cancers (Ao et al. 2018; Chang et al. 2016). Y Nezu et al. concluded that the expression levels of THBS2 and miR-135b were related with poor prognosis in liposarcomas (MLS) patients (Nezu et al. 2016). THBS2 may be also used as underlying therapeutic targets for lung cancer (Jiang et al. 2019). In this study, SPP1, COL1A1 and THBS2 were identified and their association with poor prognosis of LUAD was also sorted out, making them better candidates as diagnostic biomarkers.