China
Africa
Explore chapters and articles related to this topic
Waterborne Polyurethane for Biomedical Applications
Published in Ram K. Gupta, Ajay Kumar Mishra, Eco-Friendly Waterborne Polyurethanes, 2022
Abbas Mohammadi, Mahtab Eslamieh, Negar Salehi, Saman Abrishamkar
Skin is the body's first line of defense against pathogenic microorganisms that may enter the body through wounds or skin damages. Wound healing is a complex, dynamic, and physiological response of living tissue to an injury. In general, the wound healing process is classified into four stages: homeostasis, inflammation, proliferation, and remodeling. The immune system can heal the wound, but to improve the quality of the healing, accelerate the healing process, and prevent pathogens from entering the body, wound dressings are required [9]. Targeted drug delivery is a set of activities that lead to the accumulation of drugs in a specific area of the body. The main advantage of using targeted drug delivery is to increase the therapeutic effects of the drug without inducing side effects on healthy organs, tissues, or cells. In general, a targeted drug delivery system includes a targeted drug, carrier, and ligand. Polymers are good options for use as pharmaceutical carriers.
Self-Assembling Polymer–Drug Conjugates Nanomedicine for Drug Delivery
Published in Vladimir Torchilin, Handbook of Materials for Nanomedicine, 2020
Targeted drug delivery systems are important in cancer since they decrease the side effects by concentrating the drug at the desired site in the body and by providing high specificity [1]. The use of nanoparticles in this regard has been increasing because of their small size and inherent ability to extravasate through the sites not accessible to larger particles. The size of nanoparticles typically within 10–100 nm is favorable for enhanced penetration and retention (EPR) in tumor sites due to abnormalities in blood and lymphatic vasculature of the tumors (Fig. 3.1) [2, 3]. Due to the small size, nanoparticles can often escape the endosomal/lysosomal pathway [4]. The penetration of nanoparticles depends primarily on size, shape, surface charge, and the composition of the nanoparticles, etc. [5]. Nowadays, techniques are available where most of these aspects can be controlled by getting the desired kind of nanoparticles.
Applications of Protein Nanoparticles as Drug Delivery Vehicle
Published in Adwitiya Sinha, Megha Rathi, Smart Healthcare Systems, 2019
Reema Gabrani, Ritu Ghildiyal, Neetigyata Pratap, Garima Sharma, Shweta Dang
Nanoencapsulation, ionic gelation, and ultrasonication methods are the main methods that are generally used for the preparation of protein NPs. Targeted drug delivery is one of the most studied and advanced methods to deliver drug into a system. Targeted drug delivery not only helps in increasing the efficacy of the drug but also helps to minimize the possible side effects of the drug. Researchers have been continuously focusing toward a specific target due to the emergence of various diseases involving complex pathways. Delivering drug specific to the target site assists in improving the probability to treat disease. Entrapping the drug molecules into nanocarriers specifically and delivering it to the target site are major advancements, which have been made possible due to the presence of NPs. Generally, NPs are molecules of sizes ranging from 1 to 100nm.NPs have much great surface area per unit volume, which makes it more active than other molecules. NPs can be formed by a variety of materials and can have different properties depending on the coating or material used.
Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review
Published in Drying Technology, 2023
Ankit Patil, Pritam Patil, Sagar Pardeshi, Preena Shrimal, Norma Rebello, Popat B. Mohite, Aniruddha Chatterjee, Arun Mujumdar, Jitendra Naik
Drug delivery refers to the method or process used to deliver a drug to suitable sites effectively to achieve the benefits of the drug. By selecting a proper delivery method, one can often alter the degree of effectiveness of some medicines. Suitable changes could bring about pharmaceutical applications by altering the physical properties of the therapeutics.[1] Targeted drug delivery is used for delivering increased drug concentration at a particular site, which improves the efficiency of the drug at the targeted site while reducing its side effects at the non-target site. Targeting drugs is usually attained by utilizing a carrier. So, targeting drugs through a carrier system has been a significant point of research in therapeutics.[2,3] In the last few decades, many new drug delivery technologies have emerged, among which the preparation of drug particles in nanosized is more effective. Nanosized drug particles help to overcome many hurdles like low solubility and bioavailability and can provide site-specific release using a smart carriers.[4]
Anti-breast carcinoma effects of green synthesized tin nanoparticles from Calendula officinalis leaf aqueous extract inhibits MCF7, Hs 319.T, and MCF10 cells proliferation
Published in Journal of Experimental Nanoscience, 2022
Chao Zhai, Cheng Shi, Yanli Hu, Zhongxin Xu, Ruiying Wang
Regarding cancer, efforts have been made to use innovative nanomaterials (nanoparticles, nanostructures), which have a more remarkable ability to target cancer cells, to treat such patients. They kill malignant cells by irradiating them, providing a microscopic therapeutic effect within electrons [8–12]. Nanoparticles are programmed to achieve optimal therapeutic efficacy, delivering therapeutic loads to target cells. Studies have also been performed on several nanocarriers based on lipids, polymers, and peptides for delivery to the respiratory system [13–16]. Properties of nanoparticles for targeted delivery of nanoparticles to tumors motivate for targeted drug delivery in cancer treatment to kill cancer cells. In a way, that has the most minor damage to healthy cells [16,17]. One of the nanotechnology goals is to mount drugs on carriers, send them and release them into the target cell, which is called targeted drug delivery. Using nanoparticles, the drug can be intelligently delivered to the desired tissue, and improve the tissue without damaging other tissues [15–17]. The scavenging capacity of [email protected] and BHT at different concentrations expressed as percentage inhibition has been indicated in Tables 1 and 2. The nanoparticles showed a higher radical scavenging activity than the selected positive control. [email protected] scavenged DPPH with the IC50 of 157 ± 0 µg/ml which is less than that of BHT.
One-pot preparation of nano-scaled magnetic-pectin particles (Fe3O4@pectin NPs): cytotoxicity, antioxidant, and anti-liver cancer properties
Published in Journal of Experimental Nanoscience, 2022
Qiao Zhang, Wenyu Cui, Honglin Guo, Baoqing Wang, He Wang, Jimei Zhang, Wenlan Li
Regarding cancer, efforts have been made to use smart nanomaterials (nanoparticles, nanostructures), which have a greater ability to target cancer cells, to treat such patients. That is, they kill malignant cells by irradiating them, providing a microscopic therapeutic effect within electrons [11–15]. Nanoparticles are programmed to achieve optimal therapeutic efficacy, delivering therapeutic loads to target cells. Studies have also been performed on several nanocarriers based on lipids, polymers, and peptides for delivery to the respiratory system [16–19]. Properties of nanoparticles for targeted delivery of nanoparticles to tumors is the motivation for targeted drug delivery in cancer treatment to kill cancer cells. In a way, that has the least damage to healthy cells [20–24]. One of the nanotechnology goals is to mount drugs on carriers, send them and release them into the target cell, which is called targeted drug delivery. Using nanoparticles, the drug can be intelligently delivered to the desired tissue, and improve the tissue without damaging other tissues [25–30].