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Explore chapters and articles related to this topic
Preclinical Models
Published in George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos, Handbook of Small Animal Imaging, 2018
Irene Cuadrado, Jesús Egido, Jose Luis Zamorano, Carlos Zaragoza
Dementia is a pathological age-related condition, progressive and yet incurable. Common forms of dementia include Alzheimer’s disease, semantic dementia, or frontotemporal dementia, featuring a frontotemporal lobar degeneration (FTLD) of the brain. FTLD-tau is a form of FTLD in which the microtubule-associated protein tau (MAPT) does not correctly polymerize (Goedert et al. 1996). Transgenic mice overexpressing different mutated forms of FTLD-tau were found useful at the molecular level to characterize intracellular signals triggered during the progression of disease (Goedert et al. 1998; Probst et al. 2000).
Advance Methods
Published in Atsushi Kawaguchi, Multivariate Analysis for Neuroimaging Data, 2021
As an application example of meta-analysis in neurological diseases, brain morphology of Alzheimer’s disease or semantic dementia was compared with that of healthy Chapleau et al. (2016) and atrophy of the visual cortex was evaluated for Alzheimer’s disease and mild cognitive impairment Deng et al. (2016). A meta-analysis of gray matter atrophy has been conducted for subtypes of Parkinson’s disease Yu et al. (2015). Both apply CBMA for VBM.
A survey on computer vision techniques for detecting facial features towards the early diagnosis of mild cognitive impairment in the elderly
Published in Systems Science & Control Engineering, 2019
Zixiang Fei, Erfu Yang, David Day-Uei Li, Stephen Butler, Winifred Ijomah, Huiyu Zhou
Moreover, some researchers compared the emotion which was using surface facial electromyography between cognitive impaired participants and healthy control participants after watching emotional video clips. Keith et al., for example, studied the abnormality of facial muscle activity in patients with Alzheimer’s Disease (AD) (Burton & Kaszniak, 2006), reporting abnormal corrugator activity in individuals with cognitive impairment compared to a control group, while watching images or videos. Additionally, patients with cognitive impairment had difficulties in controlling their facial muscles and expressing their feelings. In a relevant research, Fiona et al. investigated psychophysiological responses (surface facial electromyography and skin conductance level) from cognitive impaired participants and healthy participants after watching emotionally video clips (Kumfor, Hazelton, Rushby, Hodges, & Piguet, 2019). They found that 25 behavioural-variant frontotemporal dementia patients showed an overall dampening of responses while semantic dementia patients showed incongruous emotions.