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Preclinical Models
Published in George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos, Handbook of Small Animal Imaging, 2018
Irene Cuadrado, Jesús Egido, Jose Luis Zamorano, Carlos Zaragoza
Dementia is a pathological age-related condition, progressive and yet incurable. Common forms of dementia include Alzheimer’s disease, semantic dementia, or frontotemporal dementia, featuring a frontotemporal lobar degeneration (FTLD) of the brain. FTLD-tau is a form of FTLD in which the microtubule-associated protein tau (MAPT) does not correctly polymerize (Goedert et al. 1996). Transgenic mice overexpressing different mutated forms of FTLD-tau were found useful at the molecular level to characterize intracellular signals triggered during the progression of disease (Goedert et al. 1998; Probst et al. 2000).
Applications of imaging genomics beyond oncology
Published in Ruijiang Li, Lei Xing, Sandy Napel, Daniel L. Rubin, Radiomics and Radiogenomics, 2019
Xiaohui Yao, Jingwen Yan, Li Shen
Frontotemporal dementia (FTD) is the second most common form of dementia characterized by progressive neuronal loss in the brain frontal (the areas behind forehead) or temporal lobes (the regions behind ears). FTD accounts for approximately 20% of young-onset dementia cases that occur more commonly between the ages of 55 and 65 [78]. The symptoms of FTD include significant problems in social and personal behavior, executive dysfunction, emotion, and language. There is also no current cure for FTD.
The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): a longitudinal study of pre-symptomatic biomarkers
Published in Journal of the Royal Society of New Zealand, 2023
Brigid Ryan, Ashleigh O’Mara Baker, Christina Ilse, Kiri L. Brickell, Hannah M. Kersten, Joanna M. Williams, Donna Rose Addis, Lynette J. Tippett, Maurice A. Curtis
Frontotemporal dementia (FTD) is an umbrella clinical term for a heterogeneous group of neurodegenerative disorders characterised by atrophy of the frontal and/or temporal lobes of the brain, accompanied by progressive deficits in behaviour, executive function, and/or language (Bang et al. 2015; Deleon and Miller 2018). FTD is a leading cause of young onset dementia (Teles Vieira et al. 2013), and accounts for approximately 3% of dementia across all ages (Hogan et al. 2016). Importantly, care partner quality of life is more severely affected by FTD than by other dementias (Riedijk et al. 2006; Liu et al. 2017). FTD includes a range of clinical, pathological, and genetic sub-types.