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Ocular Drug Delivery Systems
Published in Ambikanandan Misra, Aliasgar Shahiwala, In-Vitro and In-Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes, 2018
Shubhini A. Saraf, Jovita Kanoujia, Samipta Singh, Shailendra K. Saraf
Uveitis has been induced in guinea pigs (Vogel 2002). It may be induced in a variety of species. Lewis rats are a well-established model (Wildner, Diedrichs-Möhring, and Thurau 2008). For the induction of uveitis, retina binding protein/homologous retinas are emulsified in a complete Freund’s adjuvant. After the intradermal immunization with Freund’s adjuvant, the animals develop pan uveitis in 1–2 weeks. Choroidal/retinal inflammation, retinal vasculitis, loss of visual function, and photoreceptors are the main features of experimental autoimmune uveitis (Bansal et al. 2015). The involvement of TH17 cells in autoimmune uveitis has also been reported (Amadi-Obi et al. 2007).
Swept-source optical coherence tomography imaging of the retinochoroid and beyond
Published in Expert Review of Medical Devices, 2020
Jayesh Vira, Alessandro Marchese, Rohan Bir Singh, Aniruddha Agarwal
Retinal vasculitis has been studied with different SS-OCTA devices. In idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome, wide-field SS-OCTA showed a good correlation with fluorescein angiography in detecting areas of nonperfusion and vascular abnormalities [46]. In another paper on vascular changes in intermediate uveitis and retinal vasculitis, Tian et al. confirmed that wide-field SS-OCTA was a reliable exam to detect areas of capillary nonperfusion. However, this technique was not helpful to determine disease activity in intermediate uveitis [47].
Recent advances in wide field and ultrawide field optical coherence tomography angiography in retinochoroidal pathologies
Published in Expert Review of Medical Devices, 2021
Gagan Kalra, Francesco Pichi, Nitin Kumar Menia, Daraius Shroff, Nopasak Phasukkijwatana, Kanika Aggarwal, Aniruddha Agarwal
Retinal vasculitis is characterized by inflammation of the retinal vessels including arterioles, venules and/or capillaries. FA is a sensitive tool to assess inflammatory activity however active as well as chronic vasculitis can cause vascular leakage. Vascular leakage can lead to shadowing of non-perfusion areas, while OCTA is not limited by vascular leakage.